搜索结果: 1-5 共查到“理学 MDM2”相关记录5条 . 查询时间(0.056 秒)
CHARACTERIZATION OF THE MDM2 BINDING REGIONS OF RIBOSOMAL PROTEIN L5
RPL5 MDM2 p53
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2015/5/25
The MDM2-p53 feedback loop is a well-characterized pathway. p53 is a
transcription factor and regulates the transcriptional expression of genes that
encode proteins responsible for cellular senescen...
Alternative splicing of MDM2 during breast tumorigenesis and mammary gland *development
Genes proliferation cell cycle growth abnormal genes oncogenes and tumor suppressor protein and tumor
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2014/12/11
The regulation of genes involved in proliferation and cell cycle control plays a critical role in normal development and differentiation. Aberrant expression of genes promoting proliferation (oncogene...
DNA损伤致p53-Mdm2相互作用的非线性动力学模型
p53-Mdm2相互作用 负反馈回路 非衰减振荡和衰减振荡 非线性动力学模型
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2009/11/26
p53-Mdm2相互作用在DNA损伤的细胞响应方面起着非常重要的作用。最新实验结果表明,在受到各种辐射损伤而引起DNA损伤后,细胞中的p53蛋白浓度在单体细胞和群体细胞情况下,表现为非衰减振荡和衰减振荡两种不同的动力学行为。通过研究p53 -Mdm2负反馈回路的非线性动力学,分析了各种(特别是DNA损伤,p53和Mdm2浓度三者之间的)动力学关系,提出了一个能同时描述这两种不同动力学行为的非线性模...
Mathematical models and numerical simulations for the P53 ¡Mdm2 network
delay di® erential equation p53 Mdm2
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2009/1/4
Guardian of the genome, p53 gene, and its partners that form
the complex network involved in apoptosis and cell cycle arrest, is put
under investigation. Some relevant mathematical models are descri...
p53-MDM2结合抑制剂药效团模型的构建
p53-MDM2结合抑制剂 药效团模型 Catalyst软件
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2010/1/22
采用Catalyst软件, 选择5类共24个p53-MDM2结合抑制剂作为训练集, 经计算机建模、构象优化, 由Catalyst系统构建出药效团模型, 并对药效团进行有效性分析, 结合已知的p53-MDM2结合抑制剂的结构信息, 筛选得到含有一个芳环中心、三个疏水中心和一个氢键受体的具有较好预测能力(Correl=0.941, Config=17.530, 吟cost=150.830)的药效团模型...