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Neurexophilin1 suppresses the proliferation of hematopoietic progenitor cells
Neurexophilin Dystroglycan Hematopoiesis Hematopoietic niche
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2015/5/21
Neurexin I alpha (NRXN1α) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the neuronal system. Neurexophilins (NXPHs) bind NRXN1α. Both NRXN1α and DAG1 were expressed i...
Regulation of mammary stem/progenitor cells by p53 and parity
Biological sciences Progenitor cells Adult stem cells Breast neoplasms Li-fraumeni syndrome Mammary gland Notch proteins Tumor suppressor protein p53
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2014/12/10
Breast cancer is the most common tumor among women with inherited mutations in the p53 gene (Li-Fraumeni syndrome). The tumors represent the basal-like subtype which has been suggested to originate fr...
Prostaglandin E₂ promotes recovery of hematopoietic stem and progenitor cells after radiation exposure
hematopoiesis radiomitigation radiation
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2015/5/21
The hematopoietic system is highly proliferative, making hematopoietic stem and progenitor cells (HSPC) sensitive to radiation damage. Total body irradiation and chemotherapy, as well as the risk of r...
Transcriptional Regulation of Retinal Progenitor Cells Derived from Human Induced Pluripotent Stem Cells.
Stem Cell Human iPS Differentiation Development Retina
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2015/5/22
In order to develop effective cures for diseases and decipher disease pathology, the need exists to cultivate a better understanding of human development. Existing studies employ the use of animal mod...