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南京农业大学农学院《Bioinformatics》发表黄骥教授团队“PhasiHunter: a robust phased siRNA regulatory cascade mining tool based on multiple reference sequences”（图）
黄骥 发育 生物学过程
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2024/6/11
2023年11月，生物信息学领域知名刊物 《Bioinformatics》 在线发表了题为“PhasiHunter: a robust phased siRNA regulatory cascade mining tool based on multiple reference sequences”的研究论文。
New CRISPR-based tool inserts large DNA sequences at desired sites in cells（图）
CRISPR 新型工具 大DNA序列 PAST 基因工程
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2023/6/21
Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.
Biologists glean insight into repetitive protein sequences（图）
蛋白质 重复序列 氨基酸
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2023/6/5
About 70 percent of all human proteins include at least one sequence consisting of a single amino acid repeated many times, with a few other amino acids sprinkled in. These “low-complexity regions” ar...
Machine learning discovers new sequences to boost drug delivery（图）
机器学习 药物递送 新序列 肽 基因治疗药物
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2023/6/7
Duchenne muscular dystrophy (DMD), a rare genetic disease usually diagnosed in young boys, gradually weakens muscles across the body until the heart or lungs fail. Symptoms often show up by age 5; as ...
Molecular characterization of snowdrop lectin (GNA) and its comparison with reported lectin sequences of Amaryllidaceae
bioinformatics biotic stress Galanthus nivalis gene cloning gene sequence insecticidal activity
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2016/12/8
Plant lectins have become efficient sources of insect resistance in crops. The present study was conducted to identify, amplify, clone and characterize the plant lectin gene GNA. The lectin, present i...
Effects of Linker Sequences on Vesicle Fusion Mediated by Lipid-Anchored DNA Oligonucleotides
DNA machine synthetic biology
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2016/5/25
Synthetic lipid-oligonucleotide conjugates inserted into lipid vesicles mediate fusion when one population of vesicles displays the 5'-coupled conjugate and the other the 3'-coupled conjugate, so that...
Photosynthetic Reaction Center Mutagenesis via Chimeric Rescue of a Non-functional Rhodobacter capsulatus puf Operon with Sequences from Rhodobacter sphaeroides
photosynthesis recombination bacteria energy transfer antenna
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2016/5/23
Photosynthetically active chimeric reaction centers which utilize genetic information from both Rhodobacter capsulatus and Rb. sphaeroides puf operons were isolated using a novel method termed chimeri...
Chimeric Rescue of Rb. capsulatus Reaction Center Genes with Sequences from Rb.sphaeroides
Chimeric Rescue Rb. capsulatus Reaction Center Genes Rb.sphaeroides
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2016/5/23
Site-directed mutagenesis is becoming a very important technique in the study of photosynthetic reaction center structure-function relationships. However, there are certain disadvantages associated wi...
Complete Mitochondrial Genome Sequences of Chinese Indigenous Sheep with Different Tail Types and an Analysis of Phylogenetic Evolution in Domestic Sheep
Mitochondrial DNA Mitogenome Sheep Phylogenetic Mitochondrial Control Region
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2016/5/20
China has a long history of sheep (Ovis aries [O. aries]) breeding and an abundance of sheep genetic resources. Knowledge of the complete O. aries mitogenome should facilitate the study of the evoluti...
Genetic Diversity and Phylogenetic Analysis of South-East Asian Duck Populations Based on the mtDNA D-loop Sequences
Duck Populations D-loop Region Haplotype Mitochondrial DNA Phylogeny
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2016/12/28
The maternally inherited mitochondrial DNA (mtDNA) D–loop region is widely used for exploring genetic relationships and for investigating the origin of various animal species. Currently, domestic duck...
Search Technique Helps Researchers Find DNA Sequences in Minutes Rather Than Days
Researchers DNA Sequences Minutes Rather Than Days
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2016/2/23
Database searches for DNA sequences that can take biologists and medical researchers days can now be completed in a matter of minutes, thanks to a new search method developed by computer scientists at...
Researchers shed new light on regulation of repetitive DNA sequences
Researchers repetitive DNA sequences
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2016/2/22
A pair of studies by a team of scientists has shed new light on the nature of a particular type of DNA sequences—tandem DNA repeat arrays—that play important roles in transcription control, genome org...
Contrasting Population Structure from Nuclear Intron Sequences and mtDNA of Humpback Whales
Nuclear Intron Sequences mtDNA
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2015/12/17
Powerful analyses of population structure require information from multiple genetic loci. To help develop a
molecular toolbox for obtaining this information, we have designed universal oligonucleoti...
Accuracy of Estimating Genetic Distance between Species from Short Sequences of Mitochondrial DNA
Estimating Genetic Distance Mitochondrial DNA
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2015/12/17
Recent advances in molecular techniques allow rapid determination of genetic
divergence, and in many circumstances the polymerase chain reaction (PCR) and
DNA sequencing have become the technologi...
STABLE GROTHENDIECK POLYNOMIALS AND K-THEORETIC FACTOR SEQUENCES
STABLE GROTHENDIECK POLYNOMIALS K-THEORETIC FACTOR
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2015/12/17
We formulate a nonrecursive combinatorial rule for the expansion
of the stable Grothendieck polynomials of [Fomin-Kirillov '94] in the basis of
stable Grothendieck polynomials for partitions. This g...