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2018年冷泉港会议：神经系统的秩序与紊乱（Cold Spring Harbor conference on Brains & Behavior: Order & Disorder in the Nervous System）
2018年 冷泉港会议 神经系统
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2018/1/20
We are pleased to host the 83rd Cold Spring Harbor Symposium which will focus on Brains & Behavior: Order & Disorder in the Nervous System. Previous Cold Spring Harbor Symposia on Function & Dysfuncti...
New Gene-Editing Technology Cures Genetic Blood Disorder in Mice
New Gene-Editing Technology Cures Genetic Blood Disorder Mice
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2016/11/4
A next-generation gene-editing system developed by Carnegie Mellon University and Yale University scientists has cured a genetic blood disorder in living mice using a simple IV treatment. Unlike the p...
Faulty bioelectric signal responsible for facial defects caused by rare genetic disorder
Faulty bioelectric signal facial defects genetic disorder
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2016/2/23
Tufts University biologists have discovered the bioelectric mechanism by which the rare genetic disorder Andersen-Tawil syndrome (ATS) causes facial abnormalities, a finding that could lead to prevent...
Interplay between chaperones and protein disorder promotes the evolution of protein networks
Interplay between chaperones protein disorder promotes evolution protein networks
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2015/12/11
Evolution is driven by mutations, which lead to new protein functions but come at a cost to protein stability. Non-conservative substitutions are of interest in this regard because they may most profo...
Chemical interactions and configurational disorder in silicate melts
silicate melts structure entropy unmixing
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2015/9/10
The Thermodynamics of quasi-chemical and polymeric models are briefly reviewed. It is shown that the two
classes are mutually consistent, and that opportune conversion of the existing quasi-chemical ...
Construction of a Database of Secondary Structure Segments and Short Regions of Disorder and Analysis of Their Properties
Database Short Regions
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2015/5/27
Prediction of the secondary structure of a protein from its amino acid sequence
remains an important task. Not only did the growth of database holding only
protein sequences outpace that of solved p...
Conversation of Intrinsic Disorder in Protein Domains and Families
disorder protein domains
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2015/5/27
Protein regions which lack a fixed structure are called ‘disordered’. These intrinsically disordered regions are not only very common in many proteins, they are also crucial to the function of many pr...
Intrinsic Disorder in Transcription Factors
disorder transcription
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2015/5/26
Reported evidence suggested that high abundance of intrinsic disorder in eukaryotic genomes in comparison to bacteria and archaea may reflect the greater need for disorder-associated signaling and tra...
INTRINSIC DISORDER AND PROTEIN EVOLUTION:
Amino Acid Composition Protein Evolution Intrinsic Disorder
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2015/5/26
All twenty amino acids did not appear simultaneously in nature. Instead some of them appeared early, while others were added into the genetic code later. The amino acids that were formed by Miller (19...
Mechanisms of binding diversity in protein disorder : molecular recognition features mediating protein interaction networks
Many-to-one binding Partner selection MoRF
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2015/5/25
Intrinsically disordered proteins are proteins characterized by lack of stable tertiary structures under physiological conditions. Evidence shows that disordered proteins are not only highly involved ...
Conversation of Intrinsic Disorder in Protein Domains and Families
disorder protein domains
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2015/1/9
Protein regions which lack a fixed structure are called ‘disordered’. These intrinsically disordered regions are not only very common in many proteins, they are also crucial to the function of many pr...
Superfluid-Insulator Transition in a Commensurate One-Dimensional Bosonic System with Off-Diagonal Disorder
Quantum phase transition d lattice boson system monte carlo simulation of the superfluid
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2014/12/20
We study the nature of the superfluid-insulator quantum phase transition in a one-dimensional system of lattice bosons with off-diagonal disorder in the limit of a large integer filling factor. Monte ...
Superfluid Transition in a Bose Gas with Correlated Disorder
Three dimensional gas superfluid dielectric quantum monte carlo space simulation
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2014/12/19
The superfluid transition of a three-dimensional gas of hard-sphere bosons in a disordered medium is studied using quantum Monte Carlo methods. Simulations are performed in continuous space both in th...
Dilute Bose gas with correlated disorder: a path integral Monte Carlo study
Dilute bose gas thermodynamics integral monte carlo method the continuous space superfluids quantum
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2014/12/19
We investigate the thermodynamic properties of a dilute Bose gas in a correlated random potential using exact path integral Monte Carlo methods. The study is carried out in continuous space and disord...
MU researchers offer first analysis of new human glucose disorder
human glucose disorder MU researchers
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2014/12/1
COLUMBIA, Mo. – Glycogen storage disorders, which affect the body’s ability to process sugar and store energy, are rare metabolic conditions that frequently manifest in the first years of life. Often ...