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Genome-wide screens could reveal the liver’s secrets（图）
全基因组筛选 肝脏 再生基因
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2023/6/5
The liver’s ability to regenerate itself is legendary. Even if more than 70 percent of the organ is removed, the remaining tissue can regrow an entire new liver.
Gender and Age Effects on the Expression of Genes Related to Lipid Metabolism in Broiler’s Liver
apolipoprotein lipogenesis lipolysis
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2018/3/5
Two experiments were conducted to assess gender (Experiment 1) and age (Experiment 2) effects on the
expression of genes related to lipid metabolism in broiler chickens. The expression of fatty acid ...
2017胆汁酸受体 Keystone Symposia（2017 Keystone Symposia on Bile Acid Receptors as Signal Integrators in Liver and Metabolism）
Liver and Metabolism Bile Acid Receptors
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2017/1/17
The meeting will begin on Friday, March 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 7 with a closing plenary session f...
Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction
obesity liver steatosis insulin resistance intestinal permeability gut barrier
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2018/11/12
Background: Obesity and associated metabolic disorders are related to impairments of the intestinal barrier.
Objective: We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with...
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level
fatty liver gene expression liver injury metabolomics transaminases
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2018/11/27
Background: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental cha...
Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level
PPARα SREBP-2 Insig-1
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2015/7/2
A hypothesis that eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) lower plasma cholesterol via increased expression of the Insig-1 gene with ensuing decrease of expression of genes coding for 3...
Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
Phosphatase of Regenerating Liver PTEN Mouse Models
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2015/5/25
The addition and removal of phosphate groups is a key regulatory mechanism for many cellular processes. The balance between phosphorylation and dephosphorylation is delicate and must be maintained in ...
Effects of Castration on Expression of Lipid Metabolism Genes in the Liver of Korean Cattle
Korean Cattle Liver Bulls Steers Gene Expression
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2016/5/17
Castration induces the accumulation of body fat and deposition of intramuscular fat in Korean cattle, resulting in improved beef quality. However, little is known about the metabolic adaptations in th...
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice
choline metabolism folic acid lipid metabolism liver methylenetetrahydrofolate reductase
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2018/12/24
Background: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are larg...
Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis
palmitoleic fatty acid VLDL triacylglycerol biomarker lipogenesis stearoyl-CoA desaturase
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2018/12/19
Background: Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16:1n–7 to 16:0 [SCD1(16)] in plasma...
Protective Efficacy of Alpha-lipoic Acid against AflatoxinB1-induced Oxidative Damage in the Liver
AflatoxinB Alpha-lipoic Acid Liver Oxidative Damage Antioxidant
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2016/5/16
Alpha-lipoic acid (α-LA) is not only involved in energy metabolism, but is also a powerful antioxidant that can protect against hepatic oxidative stress induced by some drugs, toxins, or under various...
Heat Shock Protein 70 Expression is Increased in the Liver of Neonatal Intrauterine Growth Retardation Piglets
Heat Shock Protein 70 Intrauterine Growth Retardation Liver Piglet
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2016/5/10
Intrauterine growth retardation (IUGR) leads to the dysfunction in digestive system, as well as the alteration in the expression of some functional proteins. Heat shock protein 70 (Hsp70) could be ind...
Expression Profiles of the Insulin-like Growth Factor System Components in Liver Tissue during Embryonic and Postnatal Growth of Erhualian and Yorkshire Reciprocal Cross F1 Pigs
Liver Insulin-like Growth Factors Expression Patterns Pig
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2016/5/10
In Erhualian and Yorkshire reciprocal cross F1 pig populations, we examined the mRNA expression characteristic of liver-derived IGF-1, IGF-1R, IGF-2, IGF-2R and IGFBP-3 during the embryonic and postna...
The Dietary Effects of Fermented Chlorella vulgaris (CBT®) on Production Performance, Liver Lipids and Intestinal Microflora in Laying Hens
Fermented Chlorella vulgaris Laying Hen Liver Lipid Intestinal Microflora Egg Quality
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2016/5/9
Fermented Chlorella vulgaris CBT® was evaluated for its effects on egg production, egg quality, liver lipids and intestinal microflora in laying hens. One hundred and eight Hy-line Brown layers (...
Substrate-Enzyme Interaction in Pig Liver Esterase
Substrate-Enzyme Interaction Pig Liver Esterase Biomolecules
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2012/5/2
Force field and first principles molecular dynamics simulations on complexes of pig liver esterase (pig liver isoenzymes and a mutant) and selected substrates (1-phenyl-1-ethyl acetate, 1- phenyl-2-bu...