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中国科学院动物研究所专利：MONOCLONAL ANTIBODY AGAINST HUMAN PRPC AND USE THEREOF
中国科学院动物研究所 专利 人PrPC蛋白 单克隆抗体
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2024/5/31
一种抗人PrPC蛋白的单克隆抗体，能够以靶向方式降低转录因子Twist1的表达水平，并诱导巨噬细胞和NK细胞靶向直肠癌肿瘤细胞。 抗体与西妥昔单抗联合用药的抑瘤效果也优于单用抗体或西妥昔单抗。
中国科学院动物研究所专利：Delayed senescence, malignant conversion of human mesenchymal stem cells can be a resistor, its preparation and use
中国科学院动物研究所 专利 人骨髓间 充质干细胞
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2024/5/30
延缓衰老，制备恶性人骨髓间充质干细胞的方法可抗选择性。 制备方法， 第二密码子的253个氨基酸残基的FOXO3蛋白， 丝氨酸密码子编码丙氨酸突变的密码子，FOXO3蛋白密码子的第315位氨基酸残基，丝氨酸密码子编码丙氨酸突变的密码子编码2个突变中的一个突变，编码多能干细胞的基因组包括该步骤。 制备的重组间充质干细胞，并进一步提供其在移植治疗中的用途。 [附图]
Engineers devise a way to selectively turn on RNA therapies in human cells（图）
人类细胞 RNA疗法 治疗性蛋白质 癌症治疗
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2023/6/21
Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences...
New CRISPR-based map ties every human gene to its function（图）
CRISPR 人类基因 单细胞测序工具
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2023/6/5
The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including MIT's Whitehea...
管敏鑫教授课题组在Human Molecular Genetics发表基因编辑结合干细胞技术治疗耳聋的新进展（图）
管敏鑫教授 干细胞技术 人类分子遗传学 973项目
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2022/9/15
2022年4月25日，浙江大学遗传学研究所管敏鑫教授课题组在国际权威学术期刊《人类分子遗传学》（Human Molecular Genetics）在线发表聋相关基因编辑结合干细胞技术的最新研究成果，该研究通过CRISPR/Cas9 基因编辑技术对线粒体修饰基因突变进行遗传矫正，在内耳毛细胞样细胞中实现听觉功能重塑，为耳聋的基因治疗带来“新的曙光”，是领域内的重要突破。
Revising the lifecycle of an important human parasite（图）
寄生虫 生命周期 隐孢子虫
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2023/7/11
“We have been interested in the romantic life of the parasite Cryptosporidium for some time,” says Boris Striepen, a scientist in Penn’s School of Veterinary Medicine.
Only one human fat cell subtype responds to insulin stimulation
AdipoPLIN fat cells insulin diabetes
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2021/8/11
It is well known that fat cells can influence our sensitivity to insulin. Now, researchers have discovered that there are three different subtypes of mature fat cells in white adipose tissue and that ...
Drug-resistant bacteria found in the guts of lemurs who live around humans The more human interaction they had, the higher the proportion of resistant bugs
antibiotics resistance lemur gut microbiota
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2021/8/10
Researchers have found evidence for antibiotic resistance in the gut microbiomes of lemurs living close to humans. The more human contact they have, the more antibiotic resistance there is. Even capti...
Overfishing and other human pressures are severely harming many marine protected areas around the world, study finds
ecological destruction edge effect marine conservation areas MPA
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2021/8/11
A new study points to a strong 'edge effect' in marine protected areas (MPAs), sharply reducing by 60 percent the fish population living up to 1 - 1.5 km within the MPA. This significantly diminishes ...
Researchers film human viruses in liquid droplets at near-atomic detail
human viruses AAV genome
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2021/8/11
Researchers have used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved und...
New study confirms relationship between toxic pollution, climate risks to human health
toxic pollution climate risks human health
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2021/8/3
In a new study that combines assessments of the risks of toxic emissions, nontoxic emissions and people's vulnerability to them, researchers found a strong and statistically significant relationship b...
Huge volcanic eruption disrupted climate but not human evolution
volcanic eruption climate disruption human evolution
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2021/8/3
A massive volcanic eruption in Indonesia about 74,000 years ago likely caused severe climate disruption in many areas of the globe, but early human populations were sheltered from the worst effects, a...
南京农业大学动物科技学院孙少琛教授团队在《Human Reproduction Update》顶刊发表综述论文（图）
孙少琛 Human Reproduction Update 卵母细胞
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2022/3/15
2021年7月8日，南京农业大学动物科技学院孙少琛教授团队在生殖生物学科顶级学术期刊《Human Reproduction Update》（5年影响因子18.96，学科排名1/83）在线发表了题为The multiple roles of RAB GTPases in female and male meiosis的综述论文，全面概括和阐述了小G蛋白（单体GTP酶）RAB家族对卵母细胞成熟以及精子...
Physicists bring human-scale object to near standstill, reaching a quantum state（图）
量子态 引力 原子尺度
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2023/6/19
To the human eye, most stationary objects appear to be just that — still, and completely at rest. Yet if we were handed a quantum lens, allowing us to see objects at the scale of individual atoms, wha...
Human-driven climate change only half the picture for krill
krill climate change natural variability ecological system
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2021/8/4
New research about the fate of krill -- one of the most abundant species on Earth -- during this century has important implications for not only the Antarctic food web, but for the largest commercial ...