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THE DISCOVERY AND STUDY OF FLUVIRUCIN B1 POLYKETIDE SYNTHASE
Polyketide synthase genomic PCR
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2014/11/20
Rapidly decreasing numbers of viable therapeutic leads in the pharmaceutical pipeline demand new, sustainable methods for improved drug discovery and development. Despite vast improvements in de novo ...
Reactive Probes for Manipulating Polyketide Synthases, and Photoreactive Probes for Strained Alkyne Click Chemistry
beta-lactam beta-lactone photochemistry Polyketide
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2014/11/20
Polyketides are a broad class of natural products that have received attention from the scientific community because they are a rich mine of bioactive structures. The common thread that binds the clas...
Reactive Heterocycles for Examining Polyketide Biosynthesis
beta-lactam fluorescent polyketide site-specific labeling
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2014/11/20
Polyketides are a class of natural products that exhibit remarkable structural and functionally diversity and are highly sought after due to their medicinally important activities. For many decades no...