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代谢重编程是肿瘤的基本特征之一。肿瘤细胞即使在氧气充足的条件下仍优先通过糖酵解途径而不是线粒体氧化磷酸化产生能量,这种现象被称为Warburg效应。这种异常的代谢方式导致肿瘤细胞过度依赖葡萄糖代谢产生乳酸,并同时抑制了三羧酸(TCA)循环等氧化代谢途径,减少了细胞内氧化压力并同时产生大量用于生物合成的代谢中间体,促进肿瘤细胞的快速增殖。肿瘤细胞如何协调糖酵解以及TCA循环也一直是肿瘤代谢领域的重点...
2022年1月21日,中国科学院上海营养与健康研究所章海兵研究组在国际学术期刊Cell Death and Differentiation在线发表了题为“Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia”的研究成果。该研究揭示...
2017年6月16日,张龙实验室在Cell Death & Differentiation发表题为“SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death”的研究论文,揭示SUMO介导的核受体泛素化调控巨噬细胞凋亡。孤核受体NR4A1(nuclear receptor subfamily4,group A,memb...
The four-day Keystone Symposia conference entitled Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering focuses on three important aspects of the...
Epigenetic processes in the development of skeletal muscle have been appreciated for over a decade. DNA methylation is a major epigenetic modification important for regulating gene expression and supp...
There is a high association of heat shock on the alteration of energy and lipid metabolism. The alterations associated with thermal stress are composed of gene expression changes and adaptation throug...
Growth factors play an important role during early ovarian development and folliculogenesis, since they regulate the migration of germ cells to the gonadal ridge. They also act on follicle recruitment...
The paper presents a evolutionary simulation where the presence of ‘tags’ and an inbuilt specialisa-tion in terms of skills result in the development of ‘symbiotic’ sharing within groups of individual...
A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell c...
The onion (Allium cepa L.) constitutes an important part of the human diet and is of economic importance on the vegetable market. Methods that allow unambiguous differentiation of cultivars and bree...
The onion (Allium cepa L.) constitutes an important part of the human diet and is of economic importance on the vegetable market. Methods that allow unambiguous differentiation of cultivars and bree...
This dissertation examines the molecular mechanisms regulating Rac2 gene expression during cell differentiation and identification of a minimal cis-element required for the induction of Rac2 gene expr...
Embryonic stem cells (ESCs) have been used as a powerful tool for research including gene manipulated animal models and the study of developmental gene regulation. Among the critical regulatory factor...
he redox potential of flowers of Achillea plants was measured by means of a puncture method. Measurements were performed in 6 taxa (species and hybrids) in the stage of bud formation, full flower and ...
Molecular biology methods offer new opportunities to differentiate, identify and type bacterial species and strains. These methods use the variability of nucleic sequences of genes such as 16S rDNA, b...

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