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2017冷泉港学术会议：果蝇神经生物学（Cold Spring Harbor conference on Neurobiology of Drosophila）
2017 冷泉港 学术会议 果蝇神经生物学
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2017/2/14
We are pleased to announce the seventeenth biennial Neurobiology of Drosophila meeting, which will be held at Cold Spring Harbor Laboratory. The meeting will begin at 7:30 pm on the evening of Tuesday...
The role of notch signaling in regulating nuclear hormone receptor activity in mammalian T lymphocytes and Drosophila
Programmed cell homeostasis biological and nuclear hormone receptors and signaling pathways programmed cell death lymphocytes drosophila melanogaster model system
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2015/1/28
Regulation of programmed cell death is crucial for proper development and maintaining homeostasis of organisms. This thesis work attempts to elucidate the relationships between two evolutionarily well...
Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells
apoptosis endocycling cells p53 protein
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2015/1/7
Apoptotic cell death is an important response to genotoxic stress that prevents oncogenesis. It is known that tissues can differ in their apoptotic response, but molecular mechanisms are little unders...
Characterization of {\it midline uncoordinated\/}, a mutation affecting behavior and neuroanatomy in Drosophila
Genetics gene gene elements neurons
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2014/12/11
Genetic screens which assay behavior have been successfully used to identify genes required for neural function. This thesis is the analysis of midline uncoordinated (muc), a mutation identified for i...
Analysis of programmed cell death in Drosophila
Genes cells activate gene expression system central nervous system cell death protein
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2014/12/11
The Drosophila reaper, head involution defective ( hid), and grim genes play key roles in regulating the activation of programmed cell death. In this first part of this study we use the Gal4/UAS targe...
Cloning and characterization of GUKHolder, a novel synaptically expressed protein that interacts with Discs -Large and SCRIBBLE at the Drosophila neuromuscular junction
Neurons spatial arrangement protein tumor protein complex enzyme
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2014/12/11
Synaptic transmission between a neuron and its target is crucially dependent upon the precise spatial arrangement of proteins in the pre- and postsynaptic apparatus. PDZ domain-containing proteins suc...
Formation and plasticity of glutamatergic synapses: Characterization of the roles of beta-amyloid precursor protein, scribble, and wingless at the Drosophila neuromuscular junction
Neurons circuit static core
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2014/12/11
The flow of information through neuronal circuits relies on the ability of neurons to form synaptic connections with specific temporal and spatial properties. These properties are not static but have ...
Drosophila Wnt-1/Wingless undergoes a hydrophobic modification and is targeted to lipid rafts for secretion, a process that requires Porcupine
Glycoprotein organisms form factor cell and developmental biology acyl transferase
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2014/12/11
Wnt ligands are a family of highly conserved glycoproteins that act as morphogens to regulate development in many organisms. Drosophila Wnt-1 (Wingless) is involved in directing cell fate decisions an...
Postsynaptic mechanisms during synaptic plasticity at the Drosophila neuromuscular junction
Synaptic plasticity cells molecules cells nerve muscle
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2014/12/11
The ability of established synaptic connections to strengthen and weaken (synapse plasticity) underlies higher order behavior such as learning and memory. Several gaps remain in our understanding of t...
Characterization of bendless and interacting partners in Drosophila central synapse formation
Neurons signaling pathways websites molecular nervous system diseases diseases central synapses fiber system the neural network
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2014/12/11
Synapses are the functional units of neuronal circuits and the sites of integration for multiple signaling pathways. Understanding the molecular basis of synaptic function is critical to understanding...
The ubiquitin E3 ligase Human Homolog of Drosophila Ariadne-1 (HHARI) is a structural and functional homolog of Parkin and is required for myogenesis
Autosomal genes Parkinson's disease human beings parkinsonism E3 ubiquitin ligase neurons dopaminergic neurons
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2014/12/11
Several genes implicated in Parkinson's disease (PD) encode components of the ubiquitin-proteasome pathway. In a specific form of PD (human Autosomal Recessive Juvenile Parkinsonism, AR-JP), loss of f...
Novel developmental functions of the Drosophila SOX gene Dichaete
Cell biology a fertilized egg embryo cell state factor regulation gene subset of mammalian proteins
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2014/12/11
All multicellular life begins as a single cell—the fertilised egg, from which the adult organism develops. As a general priniciple, as embryos progess through development, changes in cellular status s...
Target Recognition and Competitive Synaptogenesis in the Drosophila Giant Fiber System
competition Drosophila giant fiber guidance synaptogenesis
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2014/12/10
The development of complex neural networks relies on a careful balance of environmental cues to guide and shape both ends of the eventual connection. However, the correct wiring of circuits whose comp...
热带地区相对湿度的季节性变化影响果蝇Drosophila jambulina体色多型性和水分平衡(英文)
Drosophila jambulina 水分平衡 色型 多型性 相对湿度 能量收支 气候适应
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2014/2/12
在印度次大陆的亚热带地区，秋天冷而干燥， 春天湿润。变温性果蝇所具有的抗干燥性有助于其度过较为干旱的气候条件。 Drosophila jambulina 具有体色二型性。已有研究表明，随湿度变化， D. jambulina热带种群始终保持体色多型性， 这与热条件下体色黑化相反，且该热带物种中体色分化频率随季节性变化，这符合黑化干燥假说。但是两种色型的D.jambulina产生这类气候适应的机理尚不...
雌性对雄性表饰的偏好性有利于性别选择。目前尚不清楚这一偏好性是否只限于雄性表饰或这一偏好性实际上是源于影响后代适合度的基因。对于雄性可直接有利于雌性或其后代适合度的交配系统而言，答案是肯定的——雌性偏好于与对气候胁迫具有更强生理抗性的雄性交配。对果蝇Drosophila biarmipes 的室内研究已经证明了求偶过程中翅斑的作用，但是其生态学意义仍然不清楚。我们检验了有翅斑与无翅斑雄性果蝇D. ...