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F-Actin regulation of SNARE-mediated insulin secretion
insulin secretion islet ERK
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2015/5/25
In response to glucose, pancreatic islet beta cells secrete insulin in a biphasic manner, and both phases are diminished in type 2 diabetes. In beta cells, cortical F-actin beneath the plasma membrane...
ADF/Cofilin Activation Regulates Actin Polymerization and Tension Development in Canine Tracheal Smooth Muscle
dissertations research thesis
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2015/5/22
The contractile activation of airway smooth muscle tissues stimulates actin polymerization and the inhibition of actin polymerization inhibits tension development. Actin depolymerizing factor (ADF) an...
Modulation of epidermal growth factor receptor function by mutations within the actin -binding domain
Genes actin internalization growth factors tyrosine phenylalanine glutamic acid phenylalanine residues
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2014/12/11
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Regulation of the actin cytoskeleton in the pollen tube
Pollen tube ovule sperm plant sexual reproduction actin cytoskeleton protein
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2014/12/11
Pollen tube growth, the process that transports the sperm cell to the ovule, is fundamental for plant sexual reproduction. The actin cytoskeleton is essential to the process of pollen tube elongation....