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近期,智能所智能微纳器件研究室张忠平研究员和王振洋研究员领导的团队在生物体核酸结构的同步原位影像分析方面取得重要进展,合成了一种具有高效生物膜穿透能力的阳离子碳量子点,实现了对活细胞及线虫体内DNA和RNA的同步荧光成像。相关研究成果发表在国际著名化学期刊《德国应用化学》 (Angew. Chem. Int. Ed.)上。这是继该团队两个月前在该杂志发表细胞及生物体多通道荧光影像分析研究成果后的又...
DNA-Based Patterning of Tethered Membrane Patches     DNA  Lipids  Lipid Bilayers  Molecular Structure  Particle Size  Surface Properties       font style='font-size:12px;'> 2016/5/25
Solid-supported lipid bilayers are useful model systems for mimicking cellular membranes; however, the interaction of the bilayer with the surface can disrupt the function of integral membrane protein...
Membrane fusion consists of a complex rearrangement of lipids and proteins that results in the merger of two lipid bilayers. We have developed a model system that employs synthetic DNA-lipid conjugate...
We recently described a strategy to prepare DNA-tethered lipid membranes either to fixed DNA on a surface or to DNA displayed on a supported bilayer [Boxer et al., J. Struct. Biol., 2009, 168, 190; Bo...
We recently introduced two approaches for tethering planar lipid bilayers as membrane patches to either a supported lipid bilayer or DNA-functionalized surface using DNA hybridization (Chung, M.; Lowe...
Specific membrane interactions such as lipid vesicle docking and fusion can be mediated by synthetic DNA-lipid conjugates as a model for the protein-driven processes that are ubiquitous in biological ...
We have developed a strategy for preparing tethered lipid bilayer membrane patches on solid surfaces by DNA hybridization. In this way, the tethered membrane patch is held at a controllable distance f...
Membrane-membrane recognition and binding are crucial in many biological processes. We report an approach to studying the dynamics of such reactions by using DNA-tethered vesicles as a general scaffol...

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