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TRANSCRIPTIONAL REGULATION OF THE HUMAN ALCOHOL DEHYDROGENASES AND ALCOHOLISM
exon arrays differential gene expression alternative splicing
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2015/5/25
Alcohol dehydrogenase (ADH) genes encode proteins that metabolize ethanol to acetaldehyde. Humans have seven ADH genes in a cluster. The hypothesis of this study was that by controlling the levels of ...
Kinetic Analysis of Primate and Ancestral Alcohol Dehydrogenases
alcohol dehydrogenase ADH primate evolution
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2015/5/25
Seven human alcohol dehydrogenase genes (which encode the primary enzymes involved in alcohol metabolism) are grouped into classes based on function and sequence identity. While the Class I ADH isoenz...
Identification of genes affected by fetal alcohol exposure during brain development
The fetus alcohol mental retardation injury mechanism the brain genes and animal models
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2014/12/11
Fetal alcohol exposure is the leading known cause of mental retardation in the western world. However, the mechanisms underlying alcohol-induced damage in fetal brain are largely unknown. The goal of ...