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Synergistic actions of apomorphine and m-chlorophenylpiperazine on ejaculation, but not penile erection in rats
Synergistic actions apomorphine and m-chlorophenylpiperazine rats
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2009/5/8
It has been suggested that dopamine (DA) and serotonin (5-HT) and their receptors, particularly D2-like and 5-HT2C receptors, may play a significant role in the control of male sexual function. The ...
The influence of castration on pharmacologically induced penile erection in the cat
Testosterone vasoactive agents cAMP cGMP
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2009/2/18
The purpose of this study was to investigate the in vivo effects of intracavernosal injections of adrenomedullin (ADM), calcitonin gene-related peptide (CGRP), nociceptin, vasoactive intestinal po...
Androgenic regulation of NO availability in rat penile erection
Rats testosterone nitric oxide
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2009/2/17
Prior studies from this laboratory, using untreated castrated (CASTRATE) rats and testosterone-treated castrated (TESTO) rats, have shown that the magnitude of the intracavernosal pressure increas...
Suppressive effects of chronic hyperprolactinemia on penile erection and yawning following administration of apomorphine to pituitary-transplanted rats
Prolactin testosterone pituitary transplantation castration
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2009/2/17
Recent studies showed in vivo and in vitro that acutely introduced prolactin (PRL) excess was capable of diminishing penile erectile function independently of the LH-testosterone (T) dynamics. In th...
Intracavernosal sildenafil facilitates penile erection independent of the nitric oxide pathway
Erectile dysfunction impotence priapism Viagra
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2008/12/29
Sildenafil, in nanomolar serum levels, is an effective phosphodiesterase type 5 inhibitor, and facilitates penile erection only during sexual stimulation. However, there is limited information on th...
Penile Erection During Transurethral Surgery
Endoscopy alpha-adrenergic agonists phenylephrine priapism
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2008/12/24
Intraoperative penile erection during endoscopic surgery, although an infrequent occurrence, is a troublesome complication and a challenge to the urologist. It is difficult to perform the procedu...
Control of Penile Erection by the Melanocortinergic System:Experimental Evidences and Therapeutic Perspectives
Penile Erection Melanocortinergic System Experimental Evidences Therapeutic Perspectives
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2008/12/22
Penile erection is the ultimate vasculo-tissular response to an integrated and complex series of physiological processes elicited by psychological, neural, and hemodynamic events (Giuliano and Rampin,...
Nitric Oxide Regulation of Penile Erection: Biology and Therapeutic Implications
Nitric Oxide Regulation Penile Erection Biology Therapeutic Implications
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2008/12/15
For approximately a decade now, substantial evidence has accrued supporting nitric oxide (NO) as the central component of a major signal transduction system that acts in the penis to mediate the erect...
Efficacy of Vardenafil and Sildenafil in Facilitating Penile Erection in an Animal Model
Pelvic nerve-mediated erection intracavernosal pressure
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2008/12/3
Vardenafil and sildenafil are potent and specific phosphodiesterase type 5 (PDE 5) inhibitors. In human penile cavernosal smooth muscle cells, we have previously shown that vardenafil has a lower bi...
Noncholinergic penile erection in mice lacking the gene for endothelial nitric oxide synthase
Noncholinergic penile erection gene endothelial nitric oxide synthase
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2008/12/1
With the current understanding that nitric oxide (NO) mediates penile erection, the endothelial isoform of NO synthase (eNOS) has been implicated in this function. We undertook this study applying t...