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Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells
neurofibromin Schwann cells mast cells
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2014/12/12
The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 (NF1). The development o...
Leptin and Mast Cells:A Novel Adipoimmune Link
Leptin Mast cells Metabolie syndrome
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2009/6/29
In addition to its role in regulating feeding behavior and energy homeostasis, leptin, an adipokine (adipose tissue-secreted cytokine) (1,2), may also control lymphocyte and macrophage functions (3). ...
Origin of Basophils and Mast Cells
basophils C/EBPα GATA-2 mast cells progenitor
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2010/11/16
Basophils and mast cells are major players in the progression of allergic disorders. Although both cell types originate from hematopoietic stem cells, their lineage commitment pathways and mechanisms ...
Mast cells in the testis, epididymis and accessory glands of the rat：effects of neonatal steroid treatment
Mast cells rat neonatal steroid treatment
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2009/2/23
Mast cells in the testis of control adult rats were found almost exclusively around subcapsular blood vessels. Discrete mast cells were distributed throughout the stroma of the epididymis and sex ...
Mast cells are increased in leukoplakia, oral submucous fibrosis, oral lichen planus and oral squamous cell carcinoma
Mast cells oral leukoplakia oral submucous fibrosis oral lichen planus oral squamous cell carcinoma
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2008/10/23
Introduction: Oral leukoplakia, submucous fibrosis (OSMF), oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) are the commonly occurring oral diseases, with characteristic clinical and h...
Targeting Human Mast Cells Expressing G-Protein-Coupled Receptors in Allergic Diseases
allergic diseases bronchial asthma GPCRs human mast cells urticaria
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2010/11/17
The G-protein-coupled receptors (GPCRs) are the largest known group of integral membrane receptor proteins and are the most common targets of pharmacotherapy. Mast cells (MCs) have been reported to pl...
Effects of Salmeterol Xinafoate and Fluticasone Propionate on Immunological Activation of Human Cultured Mast Cells
chemical mediator fluticasone GM-CSF mast cell salmeterol
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2010/11/19
Background: The clinical efficacy of combination therapy comprising a long acting β2-agonist (LABA) and corticosteroid is widely recognized for the treatment of adult asthma. Here we examine the effec...
Mast Cells in Cutaneous Allergic Vasculitis: A Case Report
allergic cutaneous vasculitis case report immunohistochemical staining leukocytoclastic vasculitis mast cell
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2010/11/19
Background: The mechanism of cutaneous allergic vasculitis still remains unclear, and to the best of our knowledge, no case has been reported in the literature in which the number of mast cells was ex...
Roles of IL-18 in Basophils and Mast Cells
basophils IL-18 mast cells nematode infection Th2 cytokines
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2010/11/18
Basophils and mast cells are effecter cells in allergen/IgE-mediated immune responses. They induce type 1 immediate immune response in airway or other organ, resulting in bronchial asthma and other al...
Production of Matrix Metalloproteinases in Human Cultured Mast Cells: Involvement of Protein Kinase C—Mitogen Activated Protein Kinase Kinase—Extracellular Signal-regulated Kinase Pathway
human cultured mast cells matrix metalloproteinase-9 membrane type matrix metalloproteinase tissue inhibitor of metalloproteinase-1 tissue inhibitor of metalloproteinase-2
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2010/11/18
We detected the de novo synthesis of MMP-9 in HCMC after stimulation with PMA and found that the synthesis was mediated through protein kinase C—mitogen activated protein kinase kinase (MEK)—ERK pathw...
Mouse bone marrow-derived mast cells acquire responsiveness to substance P after co-culture with 3T3 fibroblasts in the presence of stem cell factor
co-culture mast cells stem cell factor substance P 3T3 fibroblasts
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2010/11/29
Connective tissue-type mast cells degranulate in response to a neurogenic peptide, substance P, whereas bone marrow-derived mast cells (BMMC) do not respond to this stimulant when prepared with a comb...