搜索结果: 1-15 共查到“医学细胞生物学 treatment”相关记录15条 . 查询时间(0.187 秒)
Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: implications for subtrochanteric femoral fracture risk
subtrochanteric fractures femur bisphosphonates
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2014/12/4
Bisphosphonate (BP) treatment used to prevent bone loss in postmenopausal osteoporosis has recently been implicated in an apparent increase in subtrochanteric femoral fractures. Previous work showed t...
Mandible matrix necrosis in beagle dogs After 3-years of daily oral bisphosphonate treatment
osteonecrosis of the jaw remodeling suppression
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2014/12/4
Purpose An increasing number of reports have implicated bisphosphonates as contributing to osteonecrosis of the jaw. The goal of this study was to evaluate mandible necrosis in beagle dogs treated for...
Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra
anti-remodeling bisphosphonates animal models
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2014/12/4
Introduction Bone turnover suppression in sites that already have a low surface-based remodeling rate may lead to oversuppression that could have negative effects on the biomechanical properties of bo...
Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following three years of daily treatment
Bisphosphonates remodeling suppression
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2014/12/4
Reduced bone toughness, the energy absorption capacity of the tissue, has been consistently documented in vertebrae of animals treated with a wide range of bisphosphonate doses. Data regarding toughne...
Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate
bisphosphonates alendronate animal models
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2014/12/4
Summary One year of high-dose bisphosphonate (BPs) therapy in dogs allowed the increased accumulation of advanced glycation end-products (AGEs) and reduced postyield work-to-fracture of the cortical b...
Adverse mandibular bone effects associated with kidney disease are only partially corrected with bisphosphonate and/or calcium treatment
zolendronate c-reactive protein parathyroid hormone oral bone anti-remodeling
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2014/12/4
Background/Aims: Patients with chronic kidney disease (CKD) have high prevalence of periodontal disease that may predispose to tooth loss and inflammation. The goal of this study was to test the hypot...
One Year of Alendronate Treatment Lowers Microstructural Stresses Associated with Trabecular Microdamage Initiation
bisphosphonate bone quality
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2014/12/4
Alendronate, an anti-remodeling agent, is commonly used to treat patients suffering from osteoporosis by increasing bone mineral density. Though fracture risk is lowered, an increase in microdamage ac...
Bisphosphonate Treatment Modifies Canine Bone Mineral and Matrix Properties and their Heterogeneity
bisphosphonates bone remodeling
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2014/12/4
Bone loss and alterations in bone quality are major causes leading to bone fragility in postmenopausal women. Although bisphosphonates are well known to reduce bone turnover and prevent bone loss in p...
In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following six months of treatment in skeletally mature beagle dogs
bone remodeling bone mechanics osteoporosis treatments indentation
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2014/12/4
Raloxifene treatment has been shown previously to positively affect bone mechanical properties following one year of treatment in skeletally mature dogs. Reference point indentation (RPI) can be used ...
Targeting acute phosphatase PTEN inhibition and investigation of a novel combination treatment with Schwann cell transplantation to promote spinal cord injury repair in rats
PTEN mTOR Schwann cells transplantation neuroprotection
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2015/5/21
Human traumatic spinal cord injuries (SCI) are primarily incomplete contusion or compression injuries at the cervical spinal level, causing immediate local tissue damage and a range of potential funct...
Immunomodulatory role of leptin treatment in experimental sepsis caused by gram negative bacteria
Cytokines leptin myeloperoxidase rat sepsis
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2011/3/22
To investigate the effect of leptin treatment on circulating inflammatory cytokines and on tissue damage in experimental rat model of gram-negative sepsis. Materials and methods: Adult male Wistar rat...
The Intracellular Concentration of Components of the Ubiquitin System in A549 Culture Cells During UV Treatment
UV Treatment ubiquitin activating enzyme (E1) ubiquitin conjugating enzyme (E2)
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2009/6/30
This study attempts to determine a link between the intracellular components of the ubiquitin (Ub) system and the process of DNA repair in eukaryotes. It is possible to investigate this link in two wa...
Tc1 Cells Percentage in Patients with Cutaneous Leishmaniasis before and after Treatment with Glucantime
Glucantime and lymphocyte Tc1
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2010/4/6
Background: Various responses and different prognosis to specific treatment in different patients from one hand, and importance of IFN-γ producer cells on the other hand impressed us to study Tc1. Met...
Early treatment in asthma: How early is early?
early asthma eosinophilic inflammation inhaled corticosteroids
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2010/11/24
In the 1990s, the definition of asthma changed as we realized that asthma is fundamentally an inflammatory disorder. It was also shown in both adults and children that treatment should be initiated wi...
Treatment of idiopathic hypereosinophilic syndrome with azelastine hydrochloride and biscoclaurine alkaloids
azelastine hydrochloride biscoclaurine alkaloids idiopathic hypereosinophilic syndrome
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2010/11/24
This is the first report that suggests that azelastine hydrochloride (AZE) and biscoclaurine alkaloids (CEPH; Cepharanthin®; Kaken Shoyaku, Tokyo, Japan) are useful in the treatment of idiopathic ...