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Genetically defined mouse models of male infertility     Genetically defined mouse models  male infertility       font style='font-size:12px;'> 2009/2/23
The review has four objectives. The first objective is to summarize our studies of gene mutations that induce infertility in male mice. The second objective is to stress the power of mouse genetics ...
Recently, there is increasing evidence suggesting that oxidative sperm DNA damage is closely associated with impaired sperm function and male infertility. 8-Hydroxydeoxyguanosine (8-OHdG) is consi...
Oxidative stress and male infertility     Seminal plasma  reactive oxygen species  antioxidants  infertility       font style='font-size:12px;'> 2009/2/16
We have studied the activity of substances (superoxide dismutase [SOD], catalase [Cat], malonaldehyde, xanthine oxidase [XO], nitric oxide [NOx]) participating in oxidative stress. Seminal plasma sa...
Role of oxidative stress and antioxidants in male infertility     oxidative stress  antioxidants  male infertility       font style='font-size:12px;'> 2009/2/13
Oxygen toxicity is an inherent challenge to aerobic life, including spermatozoa, the cells responsible for propagation of the species. How this toxicity affects the spermatozoan in its interactions wi...
Spermatogenesis is collaboratively controlled by testosterone and follicle stimulating hormone. Testosterone and its immediate metabolite dihydrotestosterone affect their roles through the androge...
Clinical Male Infertility and Assisted Reproduction      Clinical Male Infertility  Assisted Reproduction       font style='font-size:12px;'> 2008/12/23
The current issue of Journal of Andrology is designated as a Special Issue on Clinical Male Infertility and Assisted Reproduction. The opportunity to create a Special Issue developed because of a ...
Atorvastatin and Male Infertility:Is There a Link?      Atorvastatin  Male Infertility       font style='font-size:12px;'> 2008/12/22
Pharmacologic agents in use in the United States undergo extensive study prior to release, regulated by the federal government. However, medications in common use often harbor effects on the reproduct...
Genes and Male Infertility:What Can Go Wrong?     Genes  Male Infertility       font style='font-size:12px;'> 2008/12/19
Normal sperm production (spermatogenesis), maturation (spermiogenesis), delivery to and passage through the female genital tract (ejaculation and sperm transport), and function (capacitation, egg pene...
Extensive research in our center at the Cleveland Clinic indicates that the seminal oxidative stress test has diagnostic and prognostic capabilities beyond those of conventional tests of sperm quality...

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