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The indazole-carboxylic acid derivative tolnidamine (TOL) has marked antispermatogenic activity in rats. Previous morphological and biochemical studies indicate that Sertoli cells are one of the tar...
The reciprocal influence between Leydig and Sertoli cells prepared from pig testis were studied by coculture of both types of cells in either plastic dishes or dishes coated with basement membrane...
The effects of synthetic salmon calcitonin on primary Sertoli cell-enriched cultures and on an established cell line (TM4 cells, derived from immature mouse Sertoli cells) were studied. Synthetic ...
The influence of different modes of FSH stimulation and cycloheximide on transferrin secretion by rat Sertoli cells was investigated using a superfusion culture system. Sertoli cells from 18-day-old...
Cytosol and nuclear receptor concentrations in Sertoli cells isolated from the testes of 15-, 25-, and 35-day-old rats were measured using hydroxylapatite separation procedures. In these cells the m...
The effect of gossypol, an experimental male contraceptive agent, on the development and maintenance of the blood-testis barrier was determined by feeding gossypol daily to prepubertal and adult gui...
Sertoli cells in vivo are highly polarized and interact with the inner (tubular) and outer (interstitial) fluids. To simulate this condition in vitro we developed a two-compartment culture system ...
Testicular regression was induced in adult hamsters by optic enucleation, short photoperiod, or melatonin injections. The melatonin injected group, while undergoing testicular regression, showed a q...
Cryptorchid or hypophysectomized rats were used as models to examine the possible relationships between germ cell development and gonadotropins in the agerelated decline in the responsiveness of t...
The activity of ornithine decarboxylase (ODC) was determined in primary cultures of bovine Sertoli cells after gonadotropin stimulation in vitro. A significant increase in both ODC activity and putr...
A new technique involving a brief hypotonic treatment was developed for obtaining pure rat Sertoli cell cultures. This method for the selective removal of the germ cells present in Sertoli cell enri...
Semen samples and blood were collected from 57 men: 23 normospermic, 20 oligospermic, 10 vasectomized, two with Klinefelter's syndrome, and two with Sertoli-cell—only syndrome. Inhibin was measure...
In the present study, a possible role of ceramide in the regulation of Sertoli cell function was investigated. Intracellular ceramide levels were increased by adding N-acetylsphingosine (C2) or by i...
The objective of this study was to determine the amount of germ cell degeneration throughout spermatogenesis in the bull and to determine if gossypol-enriched diets enhance that degeneration. Twenty...
The relationship between changes in Sertoli cell number and function and changes in circulating inhibin B concentrations was investigated following unilateral orchidectomy (UO) in the adult rhesus...

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