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ELUCIDATING MECHANISMS THAT LEAD TO PERSISTENT ANXIETY-LIKE BEHAVIOR IN RATS FOLLOWING REPEATED ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN THE BASOLATERAL AMYGDALA
anxiety corticotropin-releasing factor somatostatin amygdala basolateral amygdala
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2015/5/21
Anxiety disorders are estimated to impact 1 in 4 individuals within their lifetime. For some individuals, repeated episodes of the stress response leads to pathological anxiety and depression. The str...
Telomere Maintenance Mechanisms: Prognostic and Therapeutic Implications for the Pathologist and Oncologist
Telomere Maintenance Mechanism Neoplasia Sarcoma Glioblastoma Review
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2013/1/31
In neoplasia, telomere maintenance mechanisms (TMMs) can be prognostic and may direct therapy in the future. Two types of TMM, telomerase and recombination-based alternative lengthening of telomeres (...
Epigenetics mechanisms and degenerative diseases
Epigenetics DNA Methylation Histone Modifications DNA Methylation Rheumatoid Arthritis
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2013/1/30
Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms include histone modifications and DNA methylati...
Assessment of Molecular Signalling Mechanisms for Eosinophilia in Rottweilers
Cytokines Dogs IL-5 IFN-γ Hypereosinophilic Syndrome
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2013/2/19
Rottweilers are predisposed to eosinophilic diseases, including hypereosinophilic syndrome. The immunopathogenesis of idiopathic eosinophilia is poorly characterised in dogs and man. Studies in people...
Time-Integrated Pointers for Enabling the Analysis of Detailed Reaction Mechanisms
Time-Integrated Pointers Detailed Reaction Mechanisms
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2009/12/24
Time-Integrated Pointers for Enabling the Analysis of Detailed Reaction Mechanisms.
New approaches for representing, analyzing and visualizing complex kinetic mechanisms
complex kinetic mechanisms combustion visualization
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2009/12/24
Complex kinetic representations involving thousands of reacting species and tens of
thousands of reactions are currently required for the rational analysis of modern
combustion systems. In order t...
Molecular Mechanisms Regulating mRNA Stability: Physiological and Pathological Significance
mRNA stability AU-rich elements AU-binding proteins RNA interference microRNA computational biology
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2009/12/24
The cytoplasmic level of a messenger RNA, and hence protein, depends not only upon its rates of synthesis,processing, and transport, but its decay rate as well. mRNA decay rates are frequently not sta...
Enzymatic digestion of articular cartilage results in viscoelasticity changes that are consistent with polymer dynamics mechanisms
Enzymatic digestion articular cartilage results polymer dynamics mechanisms
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2010/2/25
These results demonstrate that enzymatic digestion alters cartilage viscoelastic properties in a manner consistent with polymer dynamics mechanisms. Future studies may expand the use of polymer dynami...
Novel Approach Combining Experiment and Simulation to Clarify the Mechanisms of Stretch-induced Arrhythmias
mechano-electric feedback stretch-activated channels optical mapping heart simulation spiral wave
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2009/8/24
Mechanical stress is known to alter the electrophysiological property of myocardium and may trigger fatal arrhythmias when an abnormal load is applied to the heart. We developed novel techniques combi...
Mechanisms of Cadmium Transport in Mammalian Cells
cadmium DMT1 ZIP14 ZIP8 gene expression transport
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2009/3/23
According to early studies on the transport of cadmium (Cd), it was suggested that iron (Fe) or calcium (Ca) transport system is important in Cd incorporation into cells based on the evidence that die...
Chemical and Biological Studies for the Molecular Mechanisms of Human Trivalent Dimethylarsenic Metabolite-Induced Cytolethality;Chemical Biology of Arsenicals
arsenic arsenite dimethylarsenic trivalent dimethylarsenic dimethylarsinous GSH chemical biology
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2009/3/23
Although inorganic arsenicals are toxic and carcinogenic in humans, inorganic arsenite (AsIII) has recently emerged as a highly effective chemotherapeutic agent for acute promyelocytic leukemia (APL)....
Mechanisms of the DNA Damage in Rat Kidney after Au Injection
Gold (Au) Copper (Cu) 8-hydroxydeoxyguanosine (8-OHdG) DNA damage Metallothionein (MT)
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2009/3/16
Au (gold) is a heavy metal and its complexes are one of the more effective medicaments available for rheumatoid arthritis, although many authors have reported serious kidney damage during the chrysoth...
Inhibition of chlamydia trachomatis growth by human interferon-α：mechanisms and synergistic effect with interferon-γ and tumor necrosis factor-α
chlamydia trachomatis growth human interferon-α synergistic effect interferon-γ and tumor necrosis factor-α
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2009/3/3
We have evaluated the effect of natural human interferon (IFN)-α on the growth of chlamydia trachomatis in human epithelial cells in vitro and revealed that IFN-α has reduced both growth and infecti...
A graph-based approach for developing adaptive representations of complex reaction mechanisms
Flux graph Graph clustering Kinetic model Adaptive reduction
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2009/12/24
A graph-based approach for developing adaptive representations of complex reaction mechanisms.
Identification of Regulatory Mechanisms of the Hepatic Response to Thermal Injury
Regulatory Mechanisms the Hepatic Response Thermal Injury
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2009/12/24
Identification of Regulatory Mechanisms of the Hepatic Response to Thermal Injury.