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Celecoxib Enhances the Chemotherapeutic Response of Cisplatin and TNF-α in SiHa Cells through Reactive Oxygen Species-Mediated Mitochondrial Pathway
cervical cancer apoptosis celecoxib cisplatin TNF-α mitochondria
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2009/4/20
Recently, many studies have shown that celecoxib induces apoptosis in various cancer cells by different mechanisms depending on the cell type. This study examined the effect of the selective COX-2 inh...
Metallothionein-IIA gene transcription in cisplatin-resistant cells and its metal-signalling mechanism by Cu(II) ion
Metallothionein-IIA gene transcription cisplatin-resistant cells metal-signalling mechanism
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2009/4/1
Increased metallothionein (MT)-IIA transcription is found in some cells with acquired resistance to cisplatin (CDDP). It is also known that mammalian MT is induced by copper. MT induction by TPA (12-O...
Analysis of Cisplatin Behavior in a Non-Small Cell Lung Cancer（NSCLC）Cell Line
cisplatin resistance NSCLC intracellular Pt accumulation Pt-DNA adduct
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2009/3/23
Cisplatin (CDDP) is an effective anticancer agent that is widely used in the treatment of testicular, ovarian, bladder and lung cancers. However the development of resistance to CDDP by tumor cells is...