搜索结果: 1-15 共查到“APE1”相关记录19条 . 查询时间(0.045 秒)
APE1在糖尿病心肌病中的研究进展
糖尿病 糖尿病心肌病 脱嘌呤/脱嘧啶核酸内切酶1 氧化应激 DNA损伤修复
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2020/12/30
糖尿病的发病率及死亡率逐年升高，作为糖尿病的重要慢性并发症之一，糖尿病心肌病的研究不断深入。糖尿病心肌病的发病机制复杂，其中氧化应激和DNA损伤是其启动和持续因素。脱嘌呤/脱嘧啶核酸内切酶1 (APE1)的两个主要功能是氧化还原与DNA修复，目前许多研究已经证实其在癌症、免疫及心血管疾病等领域起到了不可忽视的作用。APE1与糖尿病心肌病发生发展及预后紧密相连。本文主要根据近年来国内外关于APE1在...
DC-CIK联合FOLFOX6化疗治疗老年结直肠癌的疗效及对血清hCAP18和APE1自身抗体的影响
结直肠肿瘤 药物疗法 树突细胞 免疫学 细胞因子类 杀伤细胞 天然 脱嘌呤核酸 抗菌药/血液 肽生物合成 免疫组织化学 自身抗体 血液
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2020/8/14
探讨树突状细胞联合细胞因子诱导的杀伤细胞（dendritic cells/cytokine induced killer cells adoptive immunotherapy，DC-CIK）联合FOLFOX6方案（奥沙利铂+亚叶酸钙+5-氟尿嘧啶）治疗老年结直肠癌患者的疗效及对人类阳离子抗菌蛋白18（human cationic antimicrobial protein 18，hCAP18）...
Inhibition of Ape1's DNA Repair Activity as a Target in Cancer: Identification of Novel Small Molecules that have Translational Potential for Molecularly Targeted Cancer Therapy
Cancer Chemotherapy Base Excision Repair DNA Repair
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2015/5/25
The DNA Base Excision Repair (BER) pathway repairs DNA damaged by endogenous and exogenous agents including chemotherapeutic agents. Removal of the damaged base by a DNA glycosylase creates an apurini...
Mass Spectrometric Approaches to Probing the Redox Function of Ape1
mass spectrometry Ape1 E3330 NEM Labeling
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2015/5/25
Human apurinic/apyrimidinic endonuclease 1 (hApe1) is a multi-functional protein having two major functions: apurinic/apyrimidinic endonuclease activity for DNA damage repair and redox activity for ge...
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
APE1 DNA repair hematopoiesis
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2014/12/12
Ape1 is a molecule with dual functions in DNA repair and redox regulation of transcription factors. In Ape1-deficient mice, embryos do not survive beyond embryonic day 9, indicating that this molecule...
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
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2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Role of Ape1 and Base Excision Repair in the Radiation Response and Heat-radiosensitization of HeLa Cells
radiation hyperthermia DNA repair
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2014/12/12
Background: The mechanism by which heat sensitizes mammalian cells to ionizing radiation remains to be elucidated. We determined whether base excision repair (BER) is involved in heat-radiosensitizati...
Implications of Ape1 in reactive oxygen signaling response following cisplatin treatment of dorsal root ganglion neurons
ROS APE1 base excision repair neurotoxicity
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2014/12/12
Peripheral neuropathy is one of the major side-effects of the anticancer drug, cisplatin. Although previous work suggests that this neuropathy correlates with formation of DNA adducts in sensory neuro...
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress; Use of APE1 small molecule inhibitors to delineate APE1 functions
base excision repair APE1/Ref-1 oxidative stress
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2014/12/12
Oxidative DNA damage has been implicated in a number of central nervous system pathologies. The base excision repair (BER) pathway is one of the most important cellular protection mechanisms that resp...
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
APE1/Ref-1 cell signaling difference analysis
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2014/12/12
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through i...
APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process
APE1/Ref-1 NPM1 rRNA quality control
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2014/12/12
APE1/Ref-1 (hereafter, APE1), a DNA repair enzyme and a transcriptional coactivator, is a vital protein in mammals. Its role in controlling cell growth and the molecular mechanisms that fine-tune its ...
Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
APE1 Ref-1
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2014/12/12
Apurinic apyrimidinic endonuclease redox effector factor-1 (APE1/Ref-1) is involved both in the base excision repair (BER) of DNA lesions and in the eukaryotic transcriptional regulation. APE1/Ref-1 i...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
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2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme
APE1/Ref-1 DNA repair
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2014/12/12
APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has a pleiotropic role in control...
双功能基因APE1调控人骨肉瘤HOS细胞miRNAs的初步研究
脱嘌呤脱嘧啶核酸内切酶 非编码小RNA 生物信息学 骨肉瘤
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2014/10/27
比较APE1-konckdown骨肉瘤HOS细胞miRNAs表达谱的差异，初步探讨APE1可能调控的miRNAs及其涉及的功能通路。 方法 利用Ad5/F35-APE1 siRNA腺病毒敲低骨肉瘤HOS细胞中APE1的表达，采用miRNA芯片检测敲低组和对照组miRNAs表达谱的改变，qRT-PCR验证，并利用生物信息学分析差异miRNAs涉及的功能。 结果 ...