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Genome-wide analyses of PAM-relaxed Cas9 genome editors reveal substantial off-target effects by ABE8e in rice
AM-relaxed Cas9 nucleases cytosine base editor adenine base editor off-target effect whole-genome sequencing genome editing rice
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2023/7/20
PAM-relaxed Cas9 nucleases, cytosine base editors and adenine base editors are promising tools for precise genome editing in plants. However, their genome-wide off-target effects are largely unexplore...
Substantial hybridisation between wild boars (Sus scrofa scrofa) and East Balkan pigs (Sus scrofa f. domestica) in natural environment as a result of semi-wild rearing in Bulgaria
microsatellites PCR-RFLP melanocortin-1 receptor introgression local pig breed commercial pig breed
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2017/2/21
The East Balkan pig (EBP) is a traditional domestic pig breed in Bulgaria managed in semi-wild conditions and well-adapted to the continental climate and rearing on pastures. From the genetical and hi...
Substantial Effect of Melanin Influencing Factors on In vitro Melanogenesis in Muzzle Melanocytes of Differently Colored Hanwoo
Melanogenesis Nitric Oxide Hanwoo Muzzle Melanocytes Cysteine
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2016/5/10
The present study was designed to investigate the effect of α-melanocyte-stimulating hormone (α-MSH), nitric oxide (NO) and L-cysteine on melanin production and expression of related genes MC1R, Tyr, ...
A substantial export flux of particulate organic carbon linked to sinking dead copepods during winter 2007–2008 in the Amundsen Gulf (southeastern Beaufort Sea, Arctic Ocean)
southeastern Beaufort Sea particulate organic carbon
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2014/4/4
In the Arctic Ocean, vertical fluxes of particulate organic carbon (POC) remain low during the dark winter
period because POC fluxes are derived from photosynthetic production. Passively sinking dead...
A substantial export flux of particulate organic carbon linked to sinking dead copepods during winter 2007–2008 in the Amundsen Gulf (southeastern Beaufort Sea, Arctic Ocean)
A substantial export flux particulate organic carbon linked sinking dead copepods during 2007–2008 the Amundsen Gulf (southeastern Beaufort Sea, Arctic Ocean)
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2014/4/2
In the Arctic Ocean, vertical fluxes of particulate organic carbon (POC) remain low during the dark winter period because POC fluxes are derived from photosynthetic production. Passively sinking dead ...
Substantial nutrient resorption from leaves, stems and roots in a subarctic flora: what is the link with other resource economics traits?
leaching resistance nitrogen nutrient resorption organ senescence
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2011/9/23
Nutrient resorption and leaching resistance, through their roles in reducing nutrient losses, are important determinants of plant nutrient economy. However, the contributions of fine-stem and fine-roo...
Assessment, elimination and substantial reduction of occupational risks. Summary of an Agency report
Assessment elimination substantial reduction occupational risks
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2014/4/24
This report features cases from a variety of workplaces that demonstrate how a risk assessment process has led to a risk being identified and successfully eliminated or substantially reduced. The main...
Substantial job losses in 2008：weakness broadens and deepens across industries
job losses Employment losses weakness broadens
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2009/7/22
Employment losses in 2008 accelerated by year’s end as continued weakness in construction, manufacturing, and professional and business services spread into consumer-driven industries.
Substantial job losses in 2008: weakness broadens and deepens across industries
job losses 2008 industries
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2010/3/4
Employment losses in 2008 accelerated by year’s end as continued weakness in construction, manufacturing, and professional and business services spread into consumer-driven industries.
Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study
Body mass index obesity fetal overnutrition hypothesis cardiovascular disease risk Finns
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2008/12/17
Background: According to the fetal overnutrition hypothesis, intrauterine influences of maternal obesity increased lifelong obesity risk in the offspring. If the hypothesis is true, then the associati...
U.S. Department of Transportation Secretary Mary E. Peters Announces A Substantial Life-Saving Technology
crash prevention
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2007/4/11
April 5, 2007,In a move that could ultimately save up to 10,000 lives each year on U.S. roadways, the nation's top transportation official today announced plans to make new crash prevention technology...
Twenty-four–hour plasma tryptophan concentrations and ratios are below normal in obese subjects and are not normalized by substantial weight reduction
Obesity weight loss plasma tryptophan,
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2016/12/30
Plasma tryptophan concentrations and the ratio of tryptophan to other large neutral amino acids (plasma tryptophan ratio) are reportedly low in obese subjects. The plasma tryptophan ratio predicts bra...
High-, but not low-bioavailability diets enable substantial control of women’s iron absorption in relation to body iron stores, with minimal adaptation within several weeks
serum ferritin fecal ferritin ascorbic acid
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2017/1/5
Adaptation of iron absorption in response to dietary iron bioavailability is less likely in premenopausal women, who generally have lower iron stores, than in men.
Organic particles in a shallow sediment trap: Substantial loss to the dissolved phase
Organic particles shallow sediment trap Substantial loss dissolved phase
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2014/6/9
We used multivariate statistics to divide the solubilized organic matter in a shallow time-series trap into fractions derived from swimmers and from the passive flux. Most of the dissolved organic mat...