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Indicators of marginal biotin deficiency and repletion in humans:validation of 3-hydroxyisovaleric acid excretion and a leucine challenge
Biotin leucine metabolism 3-hydroxyisovaleric acid bisnorbiotin egg whites
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2016/12/19
Background: The results of clinical studies have provided evidence that marginal biotin deficiency is more common than was previously thought. A previous study of 10 subjects showed that the urin...
Marginal biotin deficiency during normal pregnancy
Pregnancy teratogenicity biotin deficiency 3-hydroxyisovaleric acid women
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2016/12/17
Background: Biotin deficiency is teratogenic in several mammalian species. Approximately 50% of pregnant women have an abnormally increased urinary excretion of 3-hydroxyisovaleric acid (3-HIA), ...