搜索结果: 136-150 共查到“知识库 生物药物学”相关记录2075条 . 查询时间(0.459 秒)
佐匹克隆片人体相对生物利用度与生物等效性研究
佐匹克隆 生物等效性 生物利用度 高效液相色谱法
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2013/11/8
考察佐匹克隆片受试制剂和参比制剂的人体相对生物利用度，评价两种制剂生物等效性。方法采用两制剂双周期交叉试验方法，20例男性健康受试者分别口服佐匹克隆片受试制剂或参比制剂15 mg，高效液相色谱荧光检测法检测血浆佐匹克隆浓度，DAS2.1药动学软件分析，并作生物等效性评价。结果受试制剂与参比制剂t1/2 分别为（4.93±2.45）和（5.46±2.51） h；Cmax分别为 （101.18±23....
Cancer and Its Treatment in Main Ancient Books of Islamic Iranian Traditional Medicine (7th to 14th Century AD)
Cancer Traditional Medicine Islamic Medicine
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2015/9/28
Islamic medicine is regarded as a comprehensive medical school with a long, glorious and worldwide reputation. Some of the physicians of this school are famous worldwide and have contributed valuable ...
椎体成形术联合唑来磷酸治疗椎体转移癌27例
唑来磷酸 经皮椎体成形术 转移癌
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2013/11/7
探讨经皮椎体成形术（PVP）联合唑来磷酸治疗椎体转移癌的临床应用价值。方法椎体转移癌患者56例，分为PVP治疗组29例，接受PVP术联合治疗组27例，接受PVP术，联合唑来磷酸4 mg加0.9%氯化钠溶液100 mL静脉滴注，每3～4周1次。手术后疼痛缓解程度应用视觉模拟评分法评估，采用日常生活自理能力（ADL）量表对治疗后患者生活质量进行评估，观察患者6个月后疼痛复发情况。结果两组患者1个月后疼...
不同地域东亚钳蝎蝎毒的双向电泳鉴定
蝎毒 东亚钳蝎 双向电泳 鉴定
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2013/11/8
利用蛋白质组学中双向电泳技术，定性鉴定、分析不同地域东亚钳蝎蝎毒活性的差别，探索不同产地蝎毒的蛋白质组成及功能差异。方法将不同产地的冷冻干燥蝎毒粉经溶解、除盐、浓缩后测定蝎毒蛋白质含量，进行定量的蝎毒鉴定。采用pH梯度等电聚焦和SDSPAGE凝胶电泳技术分离蝎毒蛋白质。银染后通过凝胶成像系统获得双向电泳凝胶图谱，用PD Quest图像分析软件比较分析，确定差异的特征蛋白点，从而定性鉴定不同产地蝎...
建立抗抑郁药A613晶型的定量测定方法，并考察其原料药晶型稳定性。方法采用差示扫描量热法，氮气气氛下，升温速率20 ℃•min－1，升温范围：40～120 ℃，参比物：铝坩埚，对抗抑郁药A613的不同晶型进行定量测定。结果测得熔点温度、熔化焓等热力学参数，样品用量在0.1～4.0 mg范围内质量与熔化焓呈线性，线性方程为Y＝－108.870 0X－4.275 8，r＝0.999 6。结...
镨三元配合物对HL60细胞生长代谢热动力学的影响
水杨酸硫代脯氨酸镨三元配合物 HL60细胞 热动力学
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2013/11/7
观察水杨酸硫代脯氨酸镨三元配合物{［Pr（C7H5O3）2（C4H6NO2S）］•2H2O }对体外培养HL60细胞生长代谢热动力学的影响。方法应用微量量热法绘制［Pr（C7H5O3）2（C4H6NO2S）］•2H2O作用时HL60细胞生长代谢产热曲线，解析生长代谢速率常数（κ）、最大热输出功率（Pmax）、达峰时间（tmax）及配合物对细胞生长代谢的抑制率（I） 等热...
The Influence of a Patient-Counseling Course on the Communication Apprehension, Outcome Expectations,and Self-Efficacy of First-Year Pharmacy Students
communication apprehension self-efficacy non-prescription medication counseling
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2018/6/12
Objectives. To evaluate first-year doctor of pharmacy (PharmD) students' communication apprehension, outcome expectations, and self-efficacy for communication over the duration of a 15-week patient-co...
An Active-Learning Assignment Requiring Pharmacy Students to Write Medicinal Chemistry Examination Questions
examination active learning medicinal chemistry
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2018/6/8
Objectives. To implement and assess the effectiveness of an assignment requiring doctor of pharmacy (PharmD) students to write examination questions for the medicinal chemistry sections of a pharmacot...
European Pharmacy Students'Experience With Virtual Patient Technology
virtual patient simulation pharmacy education Europe survey
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2018/6/7
Objective. To describe how virtual patients are being used to simulate real-life clinical scenarios in undergraduate pharmacy education in Europe.
Methods. One hundred ninety-four participants at the...
Journal Clubs During Advanced Pharmacy Practice Experiences to Teach Literature-Evaluation Skills
journal club drug information literature evaluation advanced pharmacy practice experiences
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2018/6/7
Objective. To determine pharmacy students’ attitudes and academic performance related to journal club during 2 advanced pharmacy practice experiences (APPEs).
Design. Fourth-year pharmacy students we...
The Impact of Team-Based Learning on a Foundational Pharmacokinetics Course
self-directed learning cooperative learning team-based learning
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2018/6/5
Objective. To assess the impact of team-based learning (TBL) in a foundational pharmacokinetics course.
Design. The course was arranged into 5 modules based on the TBL format. Each module contained p...
Integration of Physical Assessment Within a Pathophysiology Course for Pharmacy
curriculum patient assessment physical assessment pathophysiology
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2018/6/5
Objective. To determine first-year pharmacy students’ analysis, confidence, and knowledge of patient physical assessment integrated within a pathophysiology curriculum.
Design. A prospective quasi-ex...
观察p27基因对人宫颈癌细胞HeLa增殖及凋亡的影响。方法 将已构建成功的腺病毒载体Ad-p27转染至宫颈癌细胞系HeLa细胞，Western blotting法检测病毒转染后p27蛋白在不同时间点表达;噻唑兰(MTT)法检测其对肿瘤细胞增殖的影响;流式细胞术检测其对肿瘤细胞凋亡的影响。结果 HeLa细胞成功转染进Ad-p27;在各观察的时间点内，与对照组比较，同一时间点的细胞中p27蛋白水平均显...
建立测定人血浆硝苯地平浓度的高效液相色谱-质谱串联（HPLC-MS/MS）分离法。方法以咪达唑仑为内标，血浆样品经乙腈沉淀，HPLCMS/MS分离分析。Diamonsil C18柱（2.1 mm×150 mm，5 μm），流动相：甲醇：水（77.7：23.3）；流速：0.3 mL•min－1。采用电喷雾离子源（ESI），以多离子反应监测方式（MRM）进行正离子监测，硝苯地平和内标咪...
阿莫西林克拉维酸钾胶囊的生物等效性研究
相对生物利用度 生物等效性 高效液相色谱-串联质谱法
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2012/11/2
研究两种阿莫西林克拉维酸钾胶囊的生物等效性。方法 采用2制剂2周期自身对照交叉试验设计，利用高效液相色谱-串联质谱法测定血浆中阿莫西林和克拉维酸钾药物浓度。结果 受试胶囊和参比胶囊中阿莫西林的AUC0→10分别为(19.132±4.196)，(19.001±4.076)mg·h·mL-1；AUC0→∞分别为(19.376±4.197)，(19.301±4.086)mg·h·mL-1；Cmax分别为...