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Integrating large volumes of data from diverse sources is a formidable challenge for many investigators in the field of molecular biology. Developing efficient methods for accessing and integrating th...
The last decade has witnessed numerous proteomic studies which have predicted and successfully confirmed the existence of extended structurally flexible regions in protein molecules. Parallel to these...
Intrinsically disordered proteins (IDPs) are abundant in nature, being more prevalent in the proteomes of eukaryotes than those of bacteria or archaea. As introduced in Chapter I, these proteins, or p...
DNA double strand breaks (DSB), particularly those induced by ionizing radiation (IR) are complex lesions and if not repaired, these breaks can lead to genomic instability, chromosomal abnormalities a...
Intrinsically disordered proteins are proteins characterized by lack of stable tertiary structures under physiological conditions. Evidence shows that disordered proteins are not only highly involved ...
Milk lysozyme is the ubiquitous enzyme in milk of mammals. In this study, the cDNA sequence of a new chicken-type (c-type) milk lysozyme gene (YML), was cloned from yak mammary gland tissue. A 444 bp ...
Since ancient days, domestic horses have been closely associated with human civilization. Today, horse racing is an important industry. Various genes involved in energy production and muscle contracti...
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and subsequent sub-cloning and sequencing were used in this study to analyze the molecular phylogenetic diversity and spat...
The purpose of this study was to investigate the alternative splicing in equine cordon-bleu WH2 repeat protein-like 1 (COBLL1) gene that was identified in horse muscle and blood leukocytes, and to pre...
The adrenergic receptor beta 2 (ADRB2) plays a role in various physiological responses of the muscle to exercise, such as contraction and relaxation. Given its important role in muscle function, we in...
Decorating the outside of cells like tiny antenna, a diverse community of sugar molecules acts like a telecommunications system, sending and receiving information, recognizing and responding to foreig...
UC Berkeley scientists have identified a new molecular pathway critical to aging, and confirmed that the process can be manipulated to help make old blood like new again.The researchers found tha...
In this article a variable window discrete scan statistic is introduced for a conditional scan statistic. This statistic is used to test the null hypothesis that the observations are randomly distri...
最近几年兴起的TALENs和CRISPR/Cas9基因打靶编辑技术是基因工程技术的热点。经打靶编辑后的基因可产生多种类型的突变形式,而大部分为杂合和双等位突变。同源染色体上的纯合突变可用PCR扩增产物直接测序确定,而对于杂合和双等位突变,则需要经过PCR扩增、克隆、和多样品测序等多个繁琐、耗时的步骤才能鉴定出突变基因型。针对这一问题,生命科学学院、亚热带农业生物资源保护与利用国家重点实验室博士生马...
Molecular biology methods offer new opportunities to differentiate, identify and type bacterial species and strains. These methods use the variability of nucleic sequences of genes such as 16S rDNA, b...

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