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WC1 mediates T cell activation and is required for the response of bovine gammadelta T cells to Leptospira antigen
Biological sciences T cell activation Leptospira
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2014/12/11
Workshop cluster 1 (WC1) molecules are exclusively expressed on the surface of γδ T cells. They belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multiple-gene fam...
Regulation of mammary stem/progenitor cells by p53 and parity
Biological sciences Progenitor cells Adult stem cells Breast neoplasms Li-fraumeni syndrome Mammary gland Notch proteins Tumor suppressor protein p53
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2014/12/10
Breast cancer is the most common tumor among women with inherited mutations in the p53 gene (Li-Fraumeni syndrome). The tumors represent the basal-like subtype which has been suggested to originate fr...
Regulation of the Hypothalamic Precursor Cells by HH/GLI Signaling in Post-Embryonic Zebrafish
Biological sciences Health and environmental sciences Heat-shock Hedgehog signaling Hypothalamus Neurogenesis Transgenic
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2014/12/10
The major goals of my research were to characterize the hypothalamic neural progenitors and to understand how Hh/Gli signaling plays a role in regulating cell proliferation in the hypothalamic neuroge...
WC1 Functions as a Co-Receptor and A Pattern Recognition Receptor In Bovine Gamma delta T Cells
Health and environmental sciences Endocytosis Gamma delta t cells Receptor-ligand interactions Wc1 Pattern recognition receptors
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2014/12/10
WC1 proteins specifically expressed on the surface of γδ T cells are members of group B Scavenger Receptor Cysteine Rich (SRCR) superfamily, in which receptors contain several SRCR domains in the extr...
NON-CANONICAL NOTCH SIGNALING REGULATES ACTIVATION AND DIFFERENTIATION OF PERIPHERAL CD4+ T CELLS
Notch non-canonical T cell NF-kB mTOR activation differentiation cross-talk
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2014/12/10
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activatio...
An inside job: UC-designed nanoparticles infiltrate, kill cancer cells from within（图）
cancer cells infiltrate
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2014/12/1
Conventional treatment seeks to eradicate cancer cells by drugs and therapy delivered from outside the cell, which may also affect (and potentially harm) nearby normal cells.
Decoding the emergence of metastatic cancer stem cells（图）
cancer stem cells cell
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2014/12/2
HOUSTON — (Oct. 31, 2014) — In the first study of its kind, Rice University researchers have mapped how information flows through the genetic circuits that cause cancer cells to become metastatic. The...
Decoding the emergence of metastatic cancer stem cells
cancer cells metastatic
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2014/11/10
HOUSTON — (Oct. 31, 2014) — In the first study of its kind, Rice University researchers have mapped how information flows through the genetic circuits that cause cancer cells to become metastatic. The...
Human skin cells reprogrammed directly into brain cells（图）
skin cells brain cells
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2014/12/1
ScientistshavedescribedawaytoconverthumanskincellsdirectlyintoaspecifictypeofbraincellaffectedbyHuntington’sdisease,anultimatelyfatalneurodegenerativedisorder.Unlikeothertechniquesthatturnonecelltypei...
Human skin cells reprogrammed directly into brain cells
Human skin cells brain cells
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2014/10/30
Scientists have described a way to convert human skin cells directly into a specific type of brain cell affected by Huntington’s disease, an ultimately fatal neurodegenerative disorder. Unlike other t...
A new way to extract bone-making cells from fat tissue
cells fat tissue
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2014/10/9
By sorting human fat tissue cells by their expression of a certain gene, Brown University scientists were able to retrieve a high yield of cells that showed an especially strong propensity to make bon...
High-throughput cell-sorting method can separate 10 billion bacterial cells in 30 minutes
Bacterial cells cells
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2014/10/9
UH Mānoa College of Engineering mechanical engineer Yi Zuo has developed a new, high-throughput method for sorting cells capable of separating 10 billion bacterial cells in 30 minutes.
Critical transport: Bond LSC team finds boron vital for plant stem cells, corn reproduction（图）
transport Plant stem cells corn reproduction
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2014/9/1
Carbon’s next-door neighbor on the periodic table typically receives little attention, but when it comes to corn reproduction boron fills an important role.
News From the Field Sorting cells with sound waves（图）
waves Field Sorting cells
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2014/9/1
Researchers from MIT, Pennsylvania State University, and Carnegie Mellon University have devised a new way to separate cells by exposing them to sound waves as they flow through a tiny channel. Their ...
Experiments prove 'stemness' of individual immune memory cells
Experiments prove stemness individual immune memory cells
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2014/8/14
Researchers in Germany and the U.S. have proven for the first time that specific individual cells of the immune system, termed central memory T cells, have all the essential characteristics of adult t...