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北平顶猴TRIM5基因和HIV-1感染相关性研究获进展
北平顶猴 TRIM5基因 HIV-1感染
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2009/7/16
近日,中国科学院昆明动物研究所动物模型与人类疾病机理重点实验室郑永唐研究员指导的博士研究生况轶群等人开展了中国云南境内北平顶猴TRIM5基因和HIV-1感染的相关性进行了研究。研究发现:中国云南境内北平顶猴都存在CypA假基因的cDNA通过逆转座机制插入至TRIM5基因座的3’-UTR区域的现象,形成了一个不同于鹰猴TRIM5-CypA的新型融合基因npmTRIMCyp。npmTRIMCyp融合基...
Edward H. Kaplan Receives CDC Scientific Achievement Award for Research Estimating Rate of New HIV Infections
CDC Scientific Achievement Award New HIV Infections
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2009/7/6
Edward H. Kaplan, the William N. and Marie A. Beach Professor of Management Sciences at the Yale School of Management, professor of public health at the Yale School of Medicine, and professor of engin...
昆明动物所抗HIV药物研发关键技术建立及应用取得进展
昆明动物所 抗HIV药物
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2009/6/25
核糖体失活蛋白(RIPs)抗HIV-1活性研究已有十几年的历史。RIPs类化合物代表了抗HIV/AIDS天然产物或先导化合物发展的一个重要方向。本文从介绍RIPs的酶活性及其抗HIV-1活性入手,对RIPs抗HIV-1的可能机制,从与RIPs酶活性的关系、诱导HIV-1感染细胞的凋亡及相应的信号转导、诱发活性氧的产生,以及对HIV-1整合酶的抑制作用等几个方面做了较详尽的阐述,并对RIPs的结构修...
猕猴模型在HIV疫苗研究中的应用
艾滋病 猴免疫缺陷病毒 人猴嵌合免疫缺陷病毒 疫苗 猕猴 动物模型
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2009/6/22
对HIV疫苗的研究一直是国际上艾滋病方面研究的热点和难点。动物模型则为疫苗研究必不可缺少的重要工具,缺乏合适的动物模型很大程度上制约了AIDS疫苗的研究。目前在国际上SIV或SHIV感染的猕猴模型为最常用的AIDS研究模型,受猕猴背景及病毒特性等多种因素的影响,使得以上两种模型在HIV疫苗研究中仍存在一定的局限性。为了更好地发挥猕猴模型在HIV疫苗研究中的巨大潜力,开发理想的AIDS猕猴模型已成为...
稳定表达HIV-1辅助蛋白Rev的THP-1细胞模型的建立和鉴定
Rev THP-1 稳定表达
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2009/6/22
Human immunodeficiency virus-1(HIV-1)辅助蛋白在其感染和艾滋病发病过程中起着非常重要的作用。Regulator of expression of virion proteins(Rev)作为HIV-1辅助蛋白之一,可以调节病毒结构蛋白mRNA出核转运和蛋白表达,对于病毒的复制至关重要。为研究Rev蛋白对靶细胞表型和功能的影响,本实验采用电穿孔的方法,将HIV-1...
《细胞》:科学家发现HIV入侵细胞新途径
HIV 入侵细胞 新途径
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2009/5/6
桑白皮中抗人爱滋病病毒(HIV)成分研究
桑白皮 黄酮
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2009/3/31
从中药桑白皮(Morus alba L.)的根皮中分离到6个成分,它们是:morusin(l),mulberrofuran D(2),kuwanon H(3),mulberrofuran K(4),kuwanon G(5),mulberrofuran G(6);并制备了它们的乙酰化合物和葡萄糖甙;还测定了这些化合物的体外抗人爱滋病病毒(HIV)活性和对人淋巴细胞的细胞毒活性,发现其中黄酮 moru...
HIV prevention for girls and young women in Malawi
HIV and AIDS young women Malawi
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2014/3/28
This Report Card is one in a series produced by theInternational Planned Parenthood Federation (IPPF),under the umbrella of the Global Coalition on Womenand AIDS, and with the support of the United Na...
HIV prevention for girls and young women in Kenya
HIV and AIDS young women Kenya
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2014/3/28
This Report Card is one in a series produced by the International PlannedParenthood Federation (IPPF), under the umbrella of the Global Coalitionon Women and AIDS, and with the support of the United N...
HIV prevention for girls and young women in Jamaica
HIV and AIDS young women Jamaica
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2014/3/28
Review and strengthen Jamaica's action in the light of the aspectsof the Political Declaration on HIV/AIDS from the 2 June 2006High-Level Meeting (to follow up on UNGASS) that particularlyrelate to HI...
HIV prevention for girls and young women in Indonesia
HIV and AIDS young women Indonesia
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2014/3/28
This Report Card is one in a series produced by the International PlannedParenthood Federation (IPPF), under the umbrella of the Global Coalitionon Women and AIDS, and with the support of the United N...
HIV prevention for girls and young women in India
HIV and AIDS young women India
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2014/3/28
This Report Card is one in a series produced by the InternationalPlanned Parenthood Federation (IPPF), under the umbrella of theGlobal Coalition on Women and AIDS, and with the support of the United N...
HIV prevention for girls and young women in Russia
HIV and AIDS young women Russia
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2014/3/28
This Report Card is one in a series produced by the International PlannedParenthood Federation (IPPF), under the umbrella of the Global Coalitionon Women and AIDS, and with the support of the United N...
HIV prevention for girls and young women in China
HIV and AIDS young women China
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2014/3/28
This Report Card is one in a series produced by theInternational Planned Parenthood Federation (IPPF), under the umbrella of the Global Coalition on Womenand AIDS, and with the support of the United N...