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Scientists find missing clue to how HIV hacks cells to propagate itself（图）
Scientists missing clue HIV hacks cells propagate itself
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2017/11/24
Computer modeling has helped a team of scientists, including several scholars from the University of Chicago, to decode previously unknown details about the process by which HIV forces cells to spread...
HIV通过“绑架”细胞表面分子入侵细胞
艾滋病病毒 HIV入侵细胞 磷脂酰丝氨酸
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2022/3/25
艾滋病病毒（HIV）是怎样将遗传物质注入细胞的？弄清这个问题对于艾滋病的防治十分重要。美国尤妮斯·肯尼迪·施赖弗国家儿童健康与人类发展研究所（NICHD）的研究人员在最新一期《细胞·宿主与微生物》杂志上发表论文称，他们发现了HIV入侵细胞的关键环节：为顺利突破细胞膜的阻拦，HIV会“绑架”细胞表面的磷脂酰丝氨酸分子。若这个绑架对象不存在了，病毒的入侵进程就会受到阻碍，HIV遗传物质也就无法侵入细胞...
2017艾滋病毒疫苗Keystone Symposia （2017 Keystone Symposia on HIV Vaccines ）
2017 艾滋病毒疫苗 Keystone Symposia
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2017/2/13
Despite great progress in preventing and treating HIV, new infections continue to plague communities around the world, and the need for an HIV vaccine is as urgent as ever. Several large cohorts of HI...
2017 艾滋病毒疫苗 Keystone Symposia（2017 Keystone Symposia on HIV Vaccines）
HIV Vaccines Vaccine Antigen
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2017/1/10
The meeting will begin on Sunday, March 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 30 with a closing plenary sessio...
HIV/AIDS Research: Its History & Future
Animal Retroviruses Molecular Biology
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2016/7/29
Cold Spring Harbor Laboratory (CSHL) is pleased to announce the sixth meeting on the history of science organized by the Laboratory's Genentech Center for the History of Molecular Biology and Biotechn...
Study offers clearest picture yet of how HIV defeats a cellular defender
clearest picture yet HIV defeats cellular defender
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2016/3/14
A new study offers the first atomic-scale view of an interaction between the HIV capsid – the protein coat that shepherds HIV into the nucleus of human cells – and a host protein known as cyclophilin ...
科学家揭示HIV-1黏膜感染机制
科学家 HIV-1黏膜感染
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2016/1/14
中国科学院上海巴斯德研究所王建华课题组在最新的一项研究中揭示了HIV-1黏膜感染（性传播）新机制。相关研究成果在线发表于《病毒学杂志》。研究揭示亚黏膜组织中定位的肥大细胞可以捕捉HIV-1介导病毒感染T细胞。亚黏膜定位的肥大细胞与树突状细胞、巨噬细胞一样，是HIV-1黏膜侵染首先接触的宿主细胞。
Risky Sexual Behaviour, Sexually Transmitted Infections, HIV/AIDS and Health Promotion among Students in the University of Douala
Sexually Transmitted Infections HIV
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2015/7/21
There are about 9,335 students in the University of Douala, 6,686 males and 3,832 females with a mean age of 20 years. Knowledge of the transmission of AIDS is high as indicated by 95% of the students...
The Role of HIV/AIDS Prevention Campaigns on HIV Related Behavioural Changes in Ibadan, Nigeria
HIV HIV/AIDS Prevention Campaigns
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2015/7/21
This study examined the impact of sources of AIDS education on HIV-related behavioural changes, and its implications for HIV prevention and service delivery in Nigeria. We analysed cross-sectional dat...
中国科学院武汉病毒研究所合作在HIV传播耐药研究中取得进展（图）
中国科学院武汉病毒研究所 HIV传播耐药
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2015/5/4
近期，中国科学院武汉病毒研究所研究员杨荣阁学科组与国际HIV/AIDS相关领域专家合作，在HIV传播耐药研究方面取得新的研究成果，相关论文Geographic and Temporal Trendsin the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 DrugResistance: An Individu...
第7外显子缺失影响HIV病毒限制因子TRIMCyp的功能
第7外显子缺失 HIV病毒限制因子 TRIMCyp
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2015/4/23
TRIMCyp是在哺乳动物进化过程中，由cyclophilin A (Cyp A)通过逆转座机制插入TRIM5基因后通过转录剪切产生的融合蛋白，它对逆转录病毒的复制具有物种特异性的限制能力。目前研究发现，哺乳类动物存在独立进化而来的4种形式TRIMCyp融合蛋白，分别是存在于新大陆猴的鹰猴TRIMCyp (omTRIMCyp)、存在于旧大陆猴的北平顶猴TRIMCyp (npmTRIMCyp)和TR...
A Mathematical Growth Model of the Viral Population in Early HIV-1 Infections
HIV infection population genetics Viral dynamics
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2014/12/8
In this thesis we develop a mathematical model to describe HIV-1 evolution during the first stages of infection (approximately within 40-60 days since onset), when one can assume exponential growth an...
中国科学院昆明动物研究所揭示新型HIV病毒限制因子TRIMCyp的起源和功能（图）
HIV病毒 限制因子 TRIMCyp
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2014/9/1
宿主与病毒的共同进化和博弈是病毒学家和进化学家长期感兴趣的研究课题。宿主中存在的病毒限制因子可直接作用于HIV病毒，破坏病毒正常的生活周期以达到限制病毒复制的作用。目前发现的HIV病毒限制因子有APOBEC3G、TRIM5α/TRIMCyp、ZAP、Tetherin、SAMHAD1、Mx2等。其中，TRIMCyp是比较特殊的一种HIV病毒限制因子，它由CypA基因通过逆转录作用插入TRIM5基因座...
Forced mutations doom HIV
Forced mutations doom HIV
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2014/8/14
Fifteen years ago, MIT professor John Essigmann and colleagues from the University of Washington had a novel idea for an HIV drug. They thought if they could induce the virus to mutate uncontrollably,...
Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction
HIV Nef Endothelial cells
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2015/5/21
With effective antiretroviral therapy (ART), cardiovascular diseases (CVD), are emerging as a major cause of morbidity and death in the aging population with HIV infection. Although this increase in C...