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The Effect of H1 Antagonists Carebastine and Olopatadine on Histamine Induced Expression of CC Chemokines in Cultured Human Nasal Epithelial Cells
allergic rhinitis carebastine CC chemokine histamine human nasal epithelial cells monocyte chemotactic protein-1 olopatadine RANTES
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2010/11/18
The release of RANTES and MCP-1 was significantly upregulated by histamine compared with the control group. Both carebastine and olopatadine inhibited the release of CC chemokine production to the con...
Tc1 Cells Percentage in Patients with Cutaneous Leishmaniasis before and after Treatment with Glucantime
Glucantime and lymphocyte Tc1
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2010/4/6
Background: Various responses and different prognosis to specific treatment in different patients from one hand, and importance of IFN-γ producer cells on the other hand impressed us to study Tc1. Met...
RANTES Production from Mononuclear Cells in Response to the Specific Allergen in Asthma Patients
asthma chemokine eosinophil mononuclear cells platelets RANTES
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2010/11/19
Background: Eosinophils are considered to be the major inflammatory cells in asthma. Since regulated on activation, normal T expressed and secreted (RANTES) is a potent chemoattractant for various imp...
Roles of IL-18 in Basophils and Mast Cells
basophils IL-18 mast cells nematode infection Th2 cytokines
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2010/11/18
Basophils and mast cells are effecter cells in allergen/IgE-mediated immune responses. They induce type 1 immediate immune response in airway or other organ, resulting in bronchial asthma and other al...
Adrenomedullin stimulates cyclic AMP production in the airway epithelial cells of guinea-pigs and in the human epithelial cell line
adrenomedullin airway cAMP epithelial cell guinea-pig human
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2010/11/26
This study was designed to examine the effects of adrenomedullin (AM) on airway epithelial cells. Primary cultures of guinea-pig tracheal epithelial cells and the human bronchiolar epithelial cell lin...
Differentiation of naive human CD4+ T cells into Th2 cells: The role of prostaglandin E2
interleukin naive CD4+ T cells prostaglandin E2 T-helper 2 cells
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2010/11/26
T-helper (Th) 2 cells, which produce interleukin (IL)-4, IL-5, IL-10 and IL-13 upon stimulation of their T cell receptors, play an important role in the development of human allergic diseases. However...
Role of γδ T cells in mucosal intranet
γδ T cells epithelial cells mucosal intranet γδ-/- mice
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2010/11/26
Intraepithelial γδ T cells appear to be an essential regulatory T cell subset for the induction and regulation of humoral and cellular immune responses in the mucosa-associated tissues. These cells fo...
Effect of macrolides on the expression of human leukocyte antigen-DR and costimulatory molecules on cultured human mononuclear cells
CD54 CD80 CD86 costimulatory molecules human leukocyte antigen-DR macrolides monocytes
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2010/11/25
Although the clinical effectiveness of long-term low-dose administration of macrolides for diffuse pan- bronchiolitis, sinobronchial syndrome, chronic sinusitis and otitis media with effusion has been...
Mechanical strain-induced DNA synthesis and cell proliferation in human airway smooth muscle cells through extracellular signal-regulated kinase
airway smooth muscle cell extracellular signal-regulated kinase mechanical strain
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2010/11/25
An increased airway muscle content is one of the characteristic features of airway remodeling. Proinflammatory substances, growth factors and mechanical strain promote airway muscle cell proliferation...
Blocking the CD154-CD40 interaction with anti-CD154 antibody differentially regulates interleukin-4 synthesis in T cells and IgE production in B cells
CD154 CD40 germline Cε IgE interleukin-4
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2010/11/25
Using severe combined immunodeficiency mice engrafted with peripheral blood mononuclear cells from atopic patients, we analyzed the regulatory effects of anti-CD154 antibody on the in vivo induction o...
T cells and autoimmune diseases
autoimmune disease T cell clone T cell receptor
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2010/11/25
The roles of antigen-specific immune reactions are discussed in different types of autoimmune diseases. Antigen-specific reactions of T cells are carried out at the level of clones. In this regard, we...
Differential effects of corticosteroids and theophylline on the adhesive interaction between eosinophils and endothelial cells
cell adhesion corticosteroids endothelial cells eosinophils theophyline
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2010/11/22
Corticosteroids and theophylline have been used widely for the treatment of asthma. These two classes of drugs appear to reduce the tissue infiltration of eosinophils, predominant inflammatory cells i...
The Effect of Suplatast Tosilate on TARC Production in Peripheral Blood Mononuclear Cells and TARC Plasma Levels
allergic rhinitis chemokines suplatast tosilate TARC
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2010/11/22
Suplatast tosilate significantly reduced TARC production by PBMCs. TARC mRNA was also suppressed in a concentration dependent manner. However, suplatast tosilate did not inhibit the expression of CCR-...
Tulobuterol, a β2-agonist, Attenuates Eosinophil Adhesion to Endothelial Cells
cell adhesion endothelial cells eosinophils tulobuterol β2-agonist
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2010/11/19
Background: Transdermal patches containing tulobuterol, slow-releasing β2-agonist patches, are now widely used in the treatment of asthma in Japan. Unlike inhalational β2-agonists, tulobuterol patches...
Regulatory T cells in oral and self-tolerance
active suppression autoimmunity interleukin-10 transforming growth factor-beta transgenic mice
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2010/11/29
Several mechanisms of immunologic tolerance have been proposed, including deletion, anergy and active suppression. Deletion and anergy have been reported based on data from both in vivo and in vitro e...