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New computational tool predicts cell fates and genetic perturbations(图)
细胞命运 遗传扰动 细胞发育
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2023/6/5
Perturbations of the Distal Heme Pocket in Human Myoglobin Mutants Probed by Infrared Spectroscopy of Bound CO:Correlation with Ligand Binding Kinetics
Distal Heme Pocket Human Myoglobin Mutants Probed Infrared Spectroscopy Bound CO:Correlation Ligand Binding Kinetics
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2016/5/23
The infrared spectra of CO bound to human myoglobin and myoglobin mutants at positions His-64, Val-68, Asp-60, and Lys-45 on the distal side have been measured between 100 and 300 K. Large differences...
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level
fatty liver gene expression liver injury metabolomics transaminases
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2018/11/27
Background: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental cha...
PIECEWISE SMOOTH PERTURBATIONS OF INTEGRABLE SYSTEMS
INTEGRABLE SYSTEMS PERTURBATIONS
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2015/9/29
We review several recent results showing that small piecewise smooth perturbations of integrable systems may exhibit unstable behavior on the set of initial condition
of large measure. We also presen...
Deterministic and stochastic perturbations of area preserving flows on a two-dimensional torus
Averaging Markov Process Hamiltonian Flow
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2015/9/29
We study deterministic and stochastic perturbations of incompressible flows on
a two-dimensional torus. Even in the case of purely deterministic perturbations,
the long-time behavior of such &...
Nonlinear Stochastic Perturbations of Dynamical Systems and Quasi-linear Parabolic PDE’s with a Small Parameter
Quasi linear parabolic equations parameters quasi linear initial boundary value
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2015/9/28
In this paper we describe the asymptotic behavior, in the exponential time scale, of solutions to quasi-linear parabolic equations with a small parameter at the second order term and the long time beh...
Metastability for Non-Linear Random Perturbations of Dynamical Systems
Quasi linear parabolic equation the small parameter the second order items
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2015/9/28
In this paper we describe the long time behavior of solutions to quasi-linear parabolic equations with a small parameter at the second order term and the long time behavior of the corresponding di@...
Deterministic and stochastic perturbations of area preserving flows on a two-dimensional torus
Averaging Markov Process Hamiltonian Flow Gluing Conditions Diffusion on a Graph
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2015/9/28
We study deterministic and stochastic perturbations of incompressible flows on a two-dimensional torus. Even in the case of purely deterministic perturbations, the long-time behavior of such ...
A second order expansion of the separatrix map for trigonometric perturbations of a priori unstable systems
second order expansion separatrix map for trigonometric perturbations priori unstable systems
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2015/9/25
In this paper we study a so-called separatrix map introduced by Zaslavskii-Filonenko [ZF68] and studied by Treschev and Piftankin [Tre98, Tre02,Pif06, PT07]. We derive a second order expansion of this...
Simultaneous ionospheric E- and F-layer perturbations caused by some major earthquakes in India
ionosphere E- and F-layers earthquakes-magnetic storm foF2 and foEs
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2015/9/2
The variation in nighttime ionospheric E- and F-region critical frequencies (foEs and foF2) is examined for the months of August 1988, September 1993 and May 1997 in which major earthquakes (6
Possible precursor to the March 11, 2011, Japan earthquake: ionospheric perturbations as seen by subionospheric very low frequency/low frequency propagation
Earthquake predictio Ionospheric perturbatio VLF/LF propagation
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2015/8/24
This study reports on a possible very low frequency/low frequency (VLF/LF) subionospheric precursor to a recent earthquake in Japan. As the epicenter of this large Japanese earthquake on March 11, 201...
Ionospheric perturbations associated with two huge earthquakes in Japan, using principal component analysis for multiple subionospheric VLF/LF propagation paths
Ionospheric perturbations Earthquakes Subionospheric VLF/LF propagation
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2015/8/24
The presence of ionospheric perturbations in possible association with two huge earthquakes (Noto-hanto peninsula and Niigata-chuetu-oki earthquakes) in 2007 was studied on the basis of a conventional...
Stability robustness of linear systems to real parametric perturbations
Robust parameter linear system the parameter singular value value
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2015/8/12
We consider linear time-invariant systems subject to real, parametric variations. The problem of computing the half-sidelength 1/mu_infinity of the largest stability hypercube in the parameter space i...
On maximizing a robustness measure for structured nonlinear perturbations
Nonlinear disturbance robustness robustness measure
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2015/8/12
In this paper, we propose a robustness measure for LTI systems with causal, nonlinear diagonal perturbations with finite L_2-gain. We propose an algorithm to reliably compute this quantity. We show ho...
Geological Perturbations and Consequences of Extreme and Unexpected Phenomena in the Ocean
Geological Perturbations and Consequences Extreme and Unexpected Phenomena the Ocean
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2015/8/5
Have you ever wondered how the ocean and seafloor react to rare but high energy extents, such as tsunamis, volcanic eruptions, extreme river floods, massive iceberg calving events, submarine slides an...