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中国科学院动物研究所专利：MONOCLONAL ANTIBODY AGAINST HUMAN PRPC AND USE THEREOF
中国科学院动物研究所 专利 人PrPC蛋白 单克隆抗体
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2024/5/31
一种抗人PrPC蛋白的单克隆抗体，能够以靶向方式降低转录因子Twist1的表达水平，并诱导巨噬细胞和NK细胞靶向直肠癌肿瘤细胞。 抗体与西妥昔单抗联合用药的抑瘤效果也优于单用抗体或西妥昔单抗。
Antibody Evolution Constrains Conformational Heterogeneity by Tailoring Protein Dynamics
flexibility nonlinear spectroscopy fluorscein molecular recognition
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2016/5/24
The evolution of proteins with novel function is thought to start from precursor proteins that are conformationally heterogeneous. The corresponding genes may be duplicated and then mutated to select ...
Development of a Novel, Anti-idiotypic Monoclonal Anti-prolactin Antibody That Mimics the Physiological Functions of Prolactin
Prolactin Anti-idotypic Antibody Signal Transduction
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2016/5/20
In this work, we prepared a panel of monoclonal anti-idiotypic antibodies to ovine prolactin (oPRL) by the hybridoma technique. Among these antibodies, one anti-idotypic antibody (designated B7) was c...
TSRI and Biotech Partners Find New Antibody Weapons against Marburg Virus
TSRI Biotech Partners Weapons against Marburg Virus
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2015/7/13
A new study led by scientists at The Scripps Research Institute (TSRI) identifies new immune molecules that protect against deadly Marburg virus, a relative of Ebola virus. The research provides ingre...
PURIFICATION OF SIMPL ANTIBODY AND IMMUNOFLUORESCENCE OF SIMPL SUB-CELLULAR LOCALIZATION IN RESPONSE TO TNFα- AND IL-1
SIMPL Transcriptional Co-Activator NF-kB
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2015/5/25
SIMPL is a transcriptional co-activator that alters the activity of transcription factor, NF-κB. In response to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal...
Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes
Monoclonal Anti-idiotypic Antibodies (Mab2s) Porcine Hepatocytes
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2016/5/18
B-32 is one of a panel of monoclonal anti-idiotypic antibodies to growth hormone (GH) that we developed. To characterize and identify its potential role as a novel growth hormone receptor (GHR) agonis...
Asymmetries in Chickens from Lines Selected and Relaxed for High or Low Antibody Titers to Sheep Red Blood Cells
Chicken Asymmetry Selection Wattle Stress
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2016/5/17
Wattle length, width, and area were measured to classify bilateral asymmetries in four lines of chickens. The lines were the S26 generation of White Leghorns selected for high (HAS) or low (LAS) respo...
Toward an antibody peptidase: Mechanistic studies of peptide-bond hydrolysis
Antibody peptide enzyme hydrolysis peptide peptide bond hydrolysis temperature primary amine derivatives
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2014/12/11
To maximize the probability of obtaining an antibody peptidase, an efficient assay for the hydrolysis of peptide bonds was developed. Two methods for detecting the uncatalyzed rate of hydrolysis of a ...
Tissues Expression, Polymorphisms Identification of FcRn Gene and Its Relationship with Serum Classical Swine Fever Virus Antibody Level in Pigs
Pig FcRn Anti-CSFV Expression Polymorphism Association
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2016/5/10
Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization. In this report, the 8,900 bp po...
Antibody pioneer headlines AIBN lab tour（图）
Bioengineering Nanotechnology
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2014/7/17
The Australian Institute for Bioengineering and Nanotechnology has hosted British monoclonal antibody pioneer Sir Greg Winter for a lab tour as part of a strategic collaboration with biotechnology com...
Associations of Polymorphisms in Four Immune-related Genes with Antibody Kinetics and Body Weight in Chickens
Antibody Kinetics Sheep Red Blood Cells Brucella abortus Interferon Gamma Body Weight
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2016/5/5
Four biological candidate genes, natural resistance associated macrophage protein 1 (SLC11A1 or NRAMP), prosaposin (PSAP), interferon Gamma (IFNG), and toll-like receptor 4 (TLR4), were examined to id...
Luminol Encapsulated Liposome as a Signal Generator for the Detection of Specific Antigen-antibody Reactions and Nucleotide Hybridization
Encapsulated Liposome Signal Generator Detection
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2010/9/14
Liposomes prepared with biotinylated phospholipids and luminol entrapped were shown to be of 187 nm in size, 59% of which were unilamellar and with 43% luminol trapping efficiency. Liposome prepared f...
Analysis of a HCV model with CTL and antibody responses
Analysis HCV model antibody responses
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2010/9/17
Analysis of a HCV model with CTL and antibody responses.
抗果蝇Dxl6蛋白抗体的制备及特异性分析Preparation and Specificity Analysis of Anti-Drosophila Dxl6 Antibody
SR蛋白 果蝇 Dxl6基因 原核表达 抗体制备
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2008/1/8
摘要
为了研究果蝇中SR蛋白家族新成员Dxl6的功能，通过RT-PCR得到Dxl6的全长cDNA，并根据Dxl6基因产物的功能区，分别将Dxl6中间区域（Dxl6 middle part, Dxl6MP）、Dxl6 C末端RS结构域（Dxl6 RS domain, Dxl6RSD）序列亚克隆至pGEX-4T-1(His)6C 及pET32a 表达载体中，表达和纯化获得融合蛋白。用纯化的融合蛋白...
Antibody against cholesteryl ester transfer protein (CETP) elicited by a recombinant chimeric enzyme vaccine attenuated atherosclerosis in a rabbit model.
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2007/7/28
专著信息
书名
Antibody against cholesteryl ester transfer protein (CETP) elicited by a recombinant chimeric enzyme vaccine attenuated atherosclerosis in a rabbit model.
语种
英文
撰写或编译
作者
Gaofu Q,Jun L,Xiuyun Z...