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2018年SIAM反问题暑期学校（Gene Golub SIAM Summer School 2018:Inverse Problems）
2018年 SIAM 反问题暑期 学校
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2017/12/20
The summer school aims to introduce graduate students to the mathematical and computational aspects of inverse problems, particularly modern developments that emphasize the quantification of uncertain...
Imputing Missing Data for Gene Expression Arrays
Imputing Missing Data Gene Expression Arrays
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2015/8/21
Here we describe three different methods for imputation.The first is based on a reduced rank SVD of the expression matrix, the second is based on K-nearest neighbor averaging, and the third is based o...
Averaged gene expressions for regression
Averaging Hierarchical clustering Lasso Variance reduction
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2015/8/21
Although averaging is a simple technique, it plays an important role in reducing variance. We use this essential property of averaging in regression of the DNA microarray data, which poses the challen...
Gene-centric gene-gene interaction: A model-based kernel machine method
Allele matching kernel association study gene-clustered SNPs genomic similarity reproducing kernel Hilbert space quantitative traits
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2012/11/23
Much of the natural variation for a complex trait can be explained by variation in DNA sequence levels. As part of sequence variation, gene-gene interaction has been ubiquitously observed in nature, w...
The importance of distinct modeling strategies for gene and gene-specific treatment effects in hierarchical models for microarray data
Diffierential expression EM algorithm hierarchical models random effects uncertainty
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2012/11/23
When analyzing microarray data, hierarchical models are often used to share information across genes when estimating means and variances or identifying differential expression. Many methods utilize so...
Molecular Distributions in Gene Regulatory Dynamics
Stochastic modelling；inducible/repressible operon
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2010/12/16
We show how one may analytically compute the stationary density of the distribution of molecular constituents in populations of cells in the presence of noise arising from either bursting transcriptio...
Stability and chaos in coupled two-dimensional maps on Gene Regulatory Network of bacterium E.Coli
two-dimensional maps complex networks bacterium E.Coli
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2010/4/2
The collective dynamics of coupled two-dimensional chaotic maps on complex networks is known to exhibit a rich variety of emergent properties which crucially depend on the underlying network topology....