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CHARACTERIZATION OF THE MDM2 BINDING REGIONS OF RIBOSOMAL PROTEIN L5
RPL5 MDM2 p53
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2015/5/25
The MDM2-p53 feedback loop is a well-characterized pathway. p53 is a
transcription factor and regulates the transcriptional expression of genes that
encode proteins responsible for cellular senescen...
Alternative splicing of MDM2 during breast tumorigenesis and mammary gland *development
Genes proliferation cell cycle growth abnormal genes oncogenes and tumor suppressor protein and tumor
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2014/12/11
The regulation of genes involved in proliferation and cell cycle control plays a critical role in normal development and differentiation. Aberrant expression of genes promoting proliferation (oncogene...
DNA损伤致p53-Mdm2相互作用的非线性动力学模型
p53-Mdm2相互作用 负反馈回路 非衰减振荡和衰减振荡 非线性动力学模型
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2009/11/26
p53-Mdm2相互作用在DNA损伤的细胞响应方面起着非常重要的作用。最新实验结果表明,在受到各种辐射损伤而引起DNA损伤后,细胞中的p53蛋白浓度在单体细胞和群体细胞情况下,表现为非衰减振荡和衰减振荡两种不同的动力学行为。通过研究p53 -Mdm2负反馈回路的非线性动力学,分析了各种(特别是DNA损伤,p53和Mdm2浓度三者之间的)动力学关系,提出了一个能同时描述这两种不同动力学行为的非线性模...