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UChicago scientists identify enzyme that removes molecular modifications from transfer RNA
UChicago scientists enzyme molecular modifications transfer RNA
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2016/11/4
New research by scientists from the University of Chicago demonstrates that the mammalian enzyme ALKBH1 can remove molecular modifications from transfer RNA, causing a measurable effect on protein tra...
The role of the CTD phosphatase Rrt1 and post-translational modifications in regulation of RNA polymerase II
CTD phosphatase Rtr1 MuDPIT AP-MS
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2015/5/25
RNA polymerase II (RNAPII) is regulated by multiple modifications to the C-terminal domain (CTD) of the largest subunit, Rpb1. This study has focused on the relationship between hyperphosphorylation o...
Two new requirements for producing normal ribosomes: (I) A novel helicase is needed for snoRNP biogenesis, and; (II) Pseudouridine modifications in the reaction center are important for ribosome function
Eukaryotic cells contain protein particles ribosomes RNA nucleotide pseudouridine
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2014/12/11
Eukaryotic cells contain scores of small nucleolar RNAs (snoRNAs) that are complexed with proteins in particles known as snoRNPs. SnoRNPs function in processing of ribosomal RNA (rRNA) and nucleotide ...
Siberian Sturgeon Oocyte Extract Induces Epigenetic Modifications of Porcine Somatic Cells and Improves Developmental Competence of SCNT Embryos
Epigenetic Modifications Somatic Cell Nuclear Transfer Siberian Sturgeon Oocyte Extract
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2016/5/16
Somatic cell nuclear transfer (SCNT) has generally demonstrated that a differentiated cell can convert into a undifferentiated or pluripotent state. In the SCNT experiment, nuclear reprogramming is in...