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异搏定对小鼠肝癌腹水瘤细胞系PI-PLC活性的影响
磷脂酰肌醇特异的磷脂酶C(PI-PLC) 异搏定 钙恒稳 肿瘤分化 腹水性肝癌
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2008/1/5
摘要 本文采用615近交系小鼠肝癌腹水瘤H_(ca)-F_(25)/CL-A_2细胞,测定钙拮抗剂异搏定作用前后磷脂酰肌醇特异的磷脂酶C(PI-PLC)活性的变化,并与同样处理的瘤株内钙恒稳的有关指标相比较。结果表明经异搏定处理后的A_2细胞PI-PLC活性显著降低,并与钙恒稳的指标基本呈现相应的平行变化趋势。提示PI-PLC可能参与肿瘤细胞内钙恒稳的变化过程,异搏定的作用可能与磷脂酰肌醇信号传导...
不同转移表型肺腺癌细胞PI-PLC的比较研究
PI-PLC 转移 肺腺癌细胞
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2007/12/18
摘要 实验证明钙、磷脂酰乙醇胺(PE)、磷脂酸(PA)及脱氧胆酸钠(DOC)对两种不同转移表型癌细胞磷脂酰肌醇特异的磷脂酶C(PI-PLC)的活性影响有明显差异。高转移性人肺腺癌细胞亚系(Anip_(973))比低或无转移性人肺腺癌细胞系(AGZY_(83-a))腹水型癌细胞PI-PLC活性高2.25—7.1倍。Anip_(1211)细胞培养液PI-PLC活性也大于AGZY_(83-a)。说明不同...
人全长PLCγ 1基因真核表达载体的构建及鉴定
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2007/7/25
Phospholipase C (PLC), which can hydrolyses phosphatidylinositol-4, 5-bisphosphate(PIP2) to the second messengers inositol-1,4,5- trisphosphate (IP；) and diacylglycerol(DAG), plays a pivotal role in r...
3M Completes Acquisition of Biotrace International PLC
microbiology health care
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2006/12/5
04 Dec 2006，NEMA member 3M recently announced that it has completed its acquisition of Biotrace International PLC, a Bridgend, UK-based manufacturer and supplier of industrial microbiology products us...