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Cellular strategies of protein quality control
Cellular strategies protein quality control
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2015/12/11
Eukaryotic cells must contend with a continuous stream of misfolded proteins that compromise the cellular protein homeostasis balance and jeopardize cell viability. An elaborate network of molecular c...
The role of N -linked glycans in protein quality control in the early secretory pathway
ER quality protein abnormal protein protein degradation the cavity cytosol proteasome chitosan tyrosine
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2014/12/11
The ER quality control machinery maintains the fidelity of the protein maturation process by sorting aberrant proteins for ER-associated protein degradation (ERAD), a process requiring retranslocation...
The role of the ER glucosyltransferase in the quality control of glycoprotein maturation
Pure sciences Biological sciences Endoplasmic reticulum Glycoprotein Glycoprotein glucosyltransferase 1 Protein folding Protein maturation Glucosyltransferase
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2014/12/11
N-linked glycans serve as quality control tags in the eukaryotic secretory pathway. The endoplasmic reticulum (ER) protein UDP-glucose: glycoprotein glucosyltransferase 1 (GT1) is the main enzyme that...
The Role Of Edem1 In The Quality Control And Degradation Of Misfolded Glycoproteins
Biological sciences Degradation Glycoproteins Misfolded Protein misfolding
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2014/12/10
Immature or incompletely assembled proteins that do not fold correctly are retained in the endoplasmic reticulum (ER) by quality control factors. Terminally misfolded glycoproteins are eventually sort...