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Gut permeability, obesity, and metabolic disorders: who is the chicken and who is the egg?
Gut permeability obesity metabolic disorders
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2018/11/12
Improved hygiene that leads to a reduced exposure to micro-organisms has been implicated as one possible cause for the “epidemic” of chronic inflammatory and metabolic diseases in industrialized count...
Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction
obesity liver steatosis insulin resistance intestinal permeability gut barrier
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2018/11/12
Background: Obesity and associated metabolic disorders are related to impairments of the intestinal barrier.
Objective: We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with...
Glycine protects cardiomyocytes against lethal reoxygenation injury by inhibiting mitochondrial permeability transition
reoxygenation permeability transition
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2014/3/31
Post-ischaemic reperfusion may precipitate cardiomyocyte death upon correction of intra-cellular acidosis due in part to mitochondrial permeability transition. We investigated whether
glycine, an ami...
Mitochondrial Permeability Transition Pore
Mitochondrial Permeability Transition Pore
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2014/3/31
In 1976, Hunter and Haworth first characterized the mitochondrial permeability transition in beef heart mitochondria.
In 1987, Martin Crompton et al. implied that the pore is a unique molecular entit...
Preconditioning delays Ca 2+ -induced mitochondrial permeability transition
Preconditioning Calcium (cellular) Mitochondria Apoptosis Necrosis
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2014/3/31
In protocol 1, New Zealand White rabbits underwent either no intervention (sham group) or 10 min of ischemia followed
by 5 min of reperfusion, preceded (PC) or not (C; control) by one episode of 5 mi...