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Analysis of programmed cell death in Drosophila
Genes cells activate gene expression system central nervous system cell death protein
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2014/12/11
The Drosophila reaper, head involution defective ( hid), and grim genes play key roles in regulating the activation of programmed cell death. In this first part of this study we use the Gal4/UAS targe...
Formation and plasticity of glutamatergic synapses: Characterization of the roles of beta-amyloid precursor protein, scribble, and wingless at the Drosophila neuromuscular junction
Neurons circuit static core
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2014/12/11
The flow of information through neuronal circuits relies on the ability of neurons to form synaptic connections with specific temporal and spatial properties. These properties are not static but have ...
Characterization of bendless and interacting partners in Drosophila central synapse formation
Neurons signaling pathways websites molecular nervous system diseases diseases central synapses fiber system the neural network
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2014/12/11
Synapses are the functional units of neuronal circuits and the sites of integration for multiple signaling pathways. Understanding the molecular basis of synaptic function is critical to understanding...
The ubiquitin E3 ligase Human Homolog of Drosophila Ariadne-1 (HHARI) is a structural and functional homolog of Parkin and is required for myogenesis
Autosomal genes Parkinson's disease human beings parkinsonism E3 ubiquitin ligase neurons dopaminergic neurons
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2014/12/11
Several genes implicated in Parkinson's disease (PD) encode components of the ubiquitin-proteasome pathway. In a specific form of PD (human Autosomal Recessive Juvenile Parkinsonism, AR-JP), loss of f...
Novel developmental functions of the Drosophila SOX gene Dichaete
Cell biology a fertilized egg embryo cell state factor regulation gene subset of mammalian proteins
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2014/12/11
All multicellular life begins as a single cell—the fertilised egg, from which the adult organism develops. As a general priniciple, as embryos progess through development, changes in cellular status s...
Target Recognition and Competitive Synaptogenesis in the Drosophila Giant Fiber System
competition Drosophila giant fiber guidance synaptogenesis
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2014/12/10
The development of complex neural networks relies on a careful balance of environmental cues to guide and shape both ends of the eventual connection. However, the correct wiring of circuits whose comp...