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2024年8月21日,中国科学院深圳先进技术研究院戴卓君课题组在Nature子刊Nature Chemical Biology发表题为“Degradable living plastics programmed by engineered spores”的研究工作。该工作通过对微生物进行基因编辑并产生具备极端环境耐受能力的孢子,使其可以在特定条件下分泌塑料降解酶;并通过塑料加工方法(高温、高压或有...
引导编辑系统(Prime editor, PE)作为目前应用灵活、前景广阔的新型基因组编辑工具,可以实现植物基因组任意碱基的替换以及小片段的插入和删除,并在与位点特异性重组酶耦合时展现出高效精准大片段定点插入的潜力。由于PE在植物中的编辑效率偏低,目前虽有多项研究通过不同策略来提升植物引导编辑系统的效率,但这些改进的引导编辑器依然存在位点偏好明显、普适性较差等问题,并且大多数优化集中在水稻和玉米等...
202年5月23日,中国科学院北京基因组研究所(国家生物信息中心)马利娜副研究员应Nature Reviews Molecular Cell Biology 邀请,联合章张研究员,发表题为“The contribution of databases towards understanding the universe of long non-coding RNAs”的评述,系统总结了长非编码RNA...
以作物矮化育种为标志的“绿色革命”使世界作物产量大幅度提高。但矮秆品种一般存在氮肥利用效率降低的缺点,其产量对化肥投入的依赖性很高。过高的氮肥投入不仅增加种植成本,还会造成环境污染。如何突破作物高产和氮高效协同改良的育种瓶颈,实现在减少氮肥投入的前提下提高作物产量,已成为当前农业可持续发展亟待解决的重大问题。
近期,动物科技学院姜雨教授团队在鸡泛基因组领域取得重要突破,研究论文“De novo assembly of 20 chicken genomes reveals the undetectable phenomenon for thousands of core genes on micro-chromosomes and sub-telomeric regions ”在Molecular Bio...
2018年11月3日,浙江大学生命科学研究院周琦团队在Molecular Biology and Evolution杂志在线发表题为“On the regulatory evolution of new genes throughout their life history“的文章,刻画了演化过程中物种特有的新基因是如何通过不同种类和程度的组蛋白修饰和获取新的调控序列,以逐步由组织特异性的年轻基因...
We are pleased to announce the Cold Spring Harbor Asia conference on Systems Biology of Gene Regulation & Genome Editing which will be held in Suzhou, China, located approximately 60 miles west of Sha...
Over the last 17 years, scientists and engineers have developed synthetic gene circuits that can program the functionality, performance, and behavior of living cells. Analogous to integrated circuits ...
TSRI Scientists Develop New Toolkit for Exploring Protein Biology     TSRI Scientists  Protein Biology       font style='font-size:12px;'> 2016/11/29
Scientists at The Scripps Research Institute (TSRI) have developed a broadly useful method to unmask new functional features of human proteins.Proteins carry out thousands of essential functions in ce...
HAPPI: A Bioinformatics Database Platform Enabling Network Biology Studies     Database  Genome  Regulatory network       font style='font-size:12px;'> 2015/5/26
The publication of the draft human genome consisting of 30,000 genes is merely the beginning of genome biology. A new way to understand the complexity and richness of molecular and cellular function o...
Traditional treatment strategy development for diseases involves the identification of target proteins related to disease states, and the interference of these proteins with drug molecules. Computatio...
The post genomic era has propelled us to the view that the biological systems are complex network of interacting genes, proteins and small molecules that give rise to biological form and function. The...
Conventional drug discovery focuses on single protein targets and follows a “sequence, structure, and function” paradigm for selecting best protein targets to screen lead chemical compounds. This es...
John Belote,Professor,Department of Biology at Syracuse University.He is Selected Publications:Manier,  M. K., J. M. Belote, K. S. Berben, D. Novikov, W. T. Stuartand S. S. Pitnick (2010) Resolvi...
Eleanor M. Maine,Professor,Department of Biology at Syracuse University.She is Research interests:Genetic regulation of development; cell-signaling; germline development; RNA silencing.Selected Public...

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