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Newly identified genetic variant protects against Alzheimer’s（图）
遗传变异 阿尔茨海默氏症 靶向治疗 基因工程
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2023/6/25
Anew genetic variant that protects against Alzheimer’s disease has been identified by an international team led by Harvard Medical School investigators at Massachusetts General Hospital and Massachuse...
Alzheimer’s risk gene undermines insulation of brain’s “wiring”（图）
阿尔茨海默氏症 风险基因 APOE4 脑细胞 隔离神经元
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2023/6/21
It’s well-known that carrying one copy of the APOE4 gene variant increases one’s risk for Alzheimer’s disease threefold and two copies about tenfold, but the fundamental reasons why, and what can be d...
Pathways to dementia: genetic predictors of cognitive and brain imaging endophenotypes in Alzheimer's disease
Episodic memory Amyloid plaque
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2015/5/21
Alzheimer's disease (AD) is a national priority, with nearly six million Americans affected at an annual cost of $200 billion and no available cure. A better understanding of the mechanisms underlying...
ROLE OF GENOMIC COPY NUMBER VARIATION IN ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT
Copy number variation Alzheimer's disease
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2015/5/21
Alzheimer's disease (AD) is the most common form of dementia defined by loss in memory and cognitive abilities severe enough to interfere significantly with daily life activities. Amnestic mild cognit...
阿尔茨海默病中β淀粉样前体蛋白基因外显子9、10的mRNA表达及突变研究--Expression Variation and Mutation Analysis of Exon 9 and 10 in Amyloid Precursor Protein Gene in Alzheimer′s Disease
阿尔茨海默病 β淀粉样前体蛋白基因 表达 突变
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2007/12/5
于上海地区汉人群中，探讨阿尔茨海默病(AD)患者外周血中β淀粉样前体蛋白基因外显子9、10（APP9~10）的mRNA表达水平，并作cDNA的点突变检测。采用半定量竞争性反转录聚合酶链反应(semi-quantitive competitive RT-PCR)技术测定APP9~10的mRNA表达水平；以聚合酶链反应（PCR）-限制性片段长度多态(RFLP)方法检测基因组DNA中载脂蛋白E基因(AP...