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Synthetic modifications of abietane diterpene acids to potent antimicrobial agents
Dihydroquinopimaric acid maleopimaric acid antimicrobial activity antitubercular activity M tuberculosis H(37)Rv antifungal activity docking studies
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2023/12/4
Among abietane type semisynthetic diterpenoids, a series of quinopimaric and maleopimaric acid derivatives modified at the carboxyl and carbonyl groups, and in ring E were synthesised to obtain new co...
Design, synthesis and biological evaluation of dehydroabietic acid derivative as potent vasodilatory agents
Dehydroabietic acid Vasodilation Inflammation Endothelial nitric oxide synthasec GMP
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2023/11/30
Using dehydroabietic acid as the lead compound for structural modification, 25 dehydroabietic acid derivatives were synthesized. Among them, compound D1 not only showed the strongest relaxation effect...
Curcumin - A Potent Inhibitor of Galectin-3 Expression
galectin-3 curcumin UV light alkylating agent MNNG
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2009/3/20
The expression of galectin-3, a β- galactoside binding lectin, was found to be affected by different kinds of stressors, and is strongly modified in numerous physiological and pathophysiological condi...