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Opportunities and challenges with CRISPR-Cas mediated homologous recombination based precise editing in plants and animals
CRISPR-Cas Homology directed repair (HDR) Non-homologous end joining (NHEJ) Knock-in Gemini virus replicon (GVR) Gene targeting (GT)
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2023/11/16
The genome editing has revolutionized the agriculture and human therapeutic sectors by its ability to create precise, stable and predictable mutations in the genome. It depends upon targeted double-st...
LSD1-LIKE1-mediated H3K4me2 demethylation is required for homologous recombination repair
H3K4me2 genome stability LYSINE-SPECIFIC DEMETHYLASE1-LIKE1 homologous recombination
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2024/2/29
Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin inhibits the progression of homologous recombination. The...
Parasexual Recombination in Magnaporthe oryzae
aggressiveness fitness Pyricularia oryzae
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2011/2/24
Parasexual recombination is thought to be one of the causes of variation in the pathogenicity of rice blast fungus, Magnaporthe oryzae, which breaks down resistant rice varieties. In this study, the v...