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Visionary stem cell technique offers new potential to treat blindness
Visionary stem cell technique new potential blindness
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2010/10/25
Scientists funded by the Medical Research Council (MRC) are pioneering a stem cell treatment to replace diseased parts of the retina, which could lead to a future treatment for retinal diseases that a...
TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis
allergic rhinitis epithelial cells Smad TGF-β
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2010/11/12
In the mouse model of allergic rhinitis, OVA challenge induced phosphorylation of Smad2 predominantly in epithelial cells in the nasal mucosa. In addition, the administration of an inhibitor of TGF-β ...
Inhibition of tracheal smooth muscle cell proliferation by phosphodiesterase inhibitors
phosphodiesterase inhibitors proliferation tracheal smooth muscle cells
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2010/11/29
Agents that increase intracellular cyclic 3',5'-adenosine monophosphate (cAMP), such as forskolin, prostaglandin (PG)E2, salbutamol and 8-bromo-cAMP, have been shownto inhibit the proliferation of air...
Mast cell function modulating IgE-mediated allergy
allergy FcεRI local IgE synthesis mast cell
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2010/11/29
Allergic diseases, such as atopic rhinitis, bronchial asthma and urticaria, are prevalent and increasing in frequency. Mast cells are known to play a central role in the immediate phase reaction of al...