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Sonic hedgehog参与人胰岛素样生长因子-1信号通路促使下颌骨髁突过度生长的实验研究
髁突肥大 音猬因子 人胰岛素样生长因子-1
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2018/9/30
目的:通过活体动物实验观察人胰岛素样生长因子-1(insulin-like growth factor,IGF-1) 与Sonic hedgehogxinh (Shh)介导的信号通路促进了髁突过度生长的作用。方法:制备IGF-1高表达表型转基因小鼠模型。将转基因鼠随机分为为5组:Cyclopamine刺激组;NVP-AEW541刺激组;IGF-1刺激组;Cyclopamine+IGF-1刺激组;生...
Sonic hedgehog gene-enhanced tissue engineering for bone regeneration
sonic hedgehog gene-enhanced bone regeneration
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2014/11/6
Improved methods of bone regeneration are needed in the craniofacial rehabilitation of patients with significant bone deficits secondary to tumor resection, congenital deformities, and prior to prosth...