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Pro-opiomelanocortin-derived peptides, alpha-MSH and beta-endorphin, are synthesized and secreted by Leydig cells, and are believed to have paracrine effects on Sertoli cells in the testis. Peptid...
The testicular response of Ile-de-France rams actively immunized against estradiol (E2) was evaluated during both the ovine nonbreeding season (spring) and breeding season (autumn). Plasma concentrati...
Active immunization of Ile-de-France rams against estradiol (E2) resulted in the production of E2-neutralizing antibodies and an elevation in the plasma concentrations of FSH, LH, and testosterone...
Testosterone is aromatized to estradiol in both peripheral tissues and the central nervous system. Various authors have suggested that this conversion in the male may be prerequisite for the regulat...
The roles of testosterone and estradiol in regulating prolactin concentrations were studied in acutely castrated adult male rats receiving subcutaneous Silastic implants of the sex steroids. Testost...
Free cytoplasmic estradiol receptor was determined in testicular biopsies from six adults showing various primary testicular disorders, and in testicular tissue obtained at autopsy from 18 males of ...
Steroid regulation of pituitary LH and FSH secretion in the male may be mediated via the direct action of testosterone, or via the conversion of testosterone to either dihydrotestosterone (DHT) or e...
Estradiol partially maintained the weights of the dorsolateral prostate and seminal vesicles in castrated adult male rats. One group of animals received subcutaneous injections of estradiol (0.01 ...
Studies were conducted to characterize the responses of the hypothalamic-pituitary-testicular axis to systemic injection of estradiol benzoate (EB) in the rat. Feedback effects of estrogens on the...
In an attempt to elucidate the effect of estradiol on the rat prostate, four experiments were conducted. In experiment 1, rats were orchiectomized and were given subcutaneous implants of silastic ...
Testosterone production by testicular interstitial cells incubated in vitro in the presence of 10-8 to 10-6 M 17-estradiol (E2), 17 -estradiol-3-benzoate (E2B), or benzoic acid (B) was examined. Hig...
To evaluate the effects of testosterone (T), dihydrotestosterone (DHT), and estradiol (E2) on the regulation of prostate growth and tissue composition, the following study was conducted in a nonhuma...
The functional influence of cell proteoglycan (PG) undersulfation on estradiol synthesis by immature rat Sertoli cell cultures was investigated by using sodium chlorate, an inhibitor of the active s...
The objective of this study was to investigate the role of androgens and nonandrogenic Leydig cell products in maintaining Leydig cell and macrophage numbers in the testis of the adult rat. Adult ...
We have already reported that the rate of increase in the estradiol/testosterone ratio (E2/T ratio) following human chorionic gonadotropin (hCG) injection has prognostic value in the treatment of olig...

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