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Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
folate homocysteine mutation
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2016/6/1
Down syndrome, or trisomy 21, is a complex
genetic disease resulting from the presence of 3 copies of chromosome
21. The origin of the extra chromosome is maternal in
95% of cases and is due to the...
Effect of the methylenetetrahydrofolate reductase 677C→T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample
total homocysteine tHcy metabolism
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2016/12/29
The objective of the study was to assess the effect of the polymorphism on the relations among folate intake, plasma folate concentration, and total plasma homocysteine (tHcy) concentration.
Effects of the human apolipoprotein A-I promoter G-A mutation on postprandial lipoprotein metabolism
Postprandial lipemia apolipoprotein A-I G-A mutation triacylglycerols retinyl palmitate coronary artery disease HDL cholesterol LDL cholesterol
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2016/12/19
Background: There is considerable interindividual variability in the postprandial lipid response to a fat-rich meal, and genetic factors have been considered to account for some of these effects....