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近日,上海市肿瘤研究所金浩杰研究员与René Bernards院士作为共同通讯作者在Nature Reviews Drug Discovery期刊上发表了长篇综述文章“Rational combinations of targeted cancer therapies: background, advances and challenges”,对癌症联合靶向治疗策略的背景、优势及面临的挑战进行全面...
Chemists use electricity to amp up drug manufacturing(图)     Chemists  electricity  drug manufacturing       font style='font-size:12px;'> 2017/9/5
Give your medicine a jolt. By using a technique that combines electricity and chemistry, future pharmaceuticals – including many of the top prescribed medications in the United States – soon may be ea...
Greener molecular intermediates may aid drug design     Greener  molecular intermediates  drug design       font style='font-size:12px;'> 2017/7/24
Scientists at Rice University have simplified their approach to synthesize a highly versatile family of precursors en route to biologically active compounds. Their method should make drug design and d...
Many potent anti-cancer drugs have major drawbacks — they fail to mix with water, which means they will have a limited solubility in blood, and they lack selectivity to cancer cells.Researchers at the...
X-ray studies done in part at the Department of Energy’s SLAC National Accelerator Laboratory have produced surprising insights into the workings of a hormone receptor associated with blood pressure r...
Chemists at the University of Alabama at Birmingham have designed triple-threat cancer-fighting polymer capsules that bring the promise of guided drug delivery closer to preclinical testing....
6th RSC-BMCS Fragment-based Drug Discovery meeting     Drug Discovery  medicinal chemistry       font style='font-size:12px;'> 2017/1/19
The aim of the 6th RSC-BMCS Fragment-based Drug Discovery meeting will be to continue the focus on case studies in Fragment-based Drug Discovery that have delivered compounds to late stage medicinal c...
Cell surface transporters play a key role in human health and disease, both through their impact on drug disposition and as therapeutic targets in their own right. This meeting continues on from the...
There has been an extraordinary evolution in the knowledge and tools related to drug metabolism, transport, and modeling and simulation over the past 2 decades. Industry, academic and regulatory scien...
Synthesizing useful new compounds is what pharmaceutical discovery and development is all about. Researchers at the School of Science at Indiana University-Purdue University Indianapolis have devised ...
Sphingosomes a novel approach to vesicular drug delivery     sphingosomes  drug delivery  sphingomyelin  vesicular system       font style='font-size:12px;'> 2015/7/21
Vesicular systems have been realized as extremely useful carrier systems in various scientific domains. Sphingosomes is bilayered vesicles in which an aqueous volume is entirely enclosed by membrane l...
Selection of the best and safest medicine should be one of the national economic policies in a country for good health care services. Introduction of detailed module in rational use of medicine (RUM) ...
Objective. To provide students with an opportunity to participate in medicinal chemistry research within the doctor of pharmacy (PharmD) curriculum. Design. We designed and implemented a 3-course seq...
Better proteins capture a boon for drug manufacturers(图)     proteins  drug       font style='font-size:12px;'> 2014/3/18
HOUSTON – (Jan. 22, 2014) – Rice University scientists have created a way to fine tune a process critical to the pharmaceutical industry that could save a lot of time and money.
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug deliv...

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