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Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma
coexpression cell cycle arrest multiple myeloma hyperdiploid
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2016/1/25
Multiple myeloma is a hematological cancer of plasma B cells and remains incurable. Two major subtypes of myeloma, hyperdiploid MM (HMM) and non-hyperdiploid MM (NHMM), have distinct chromosomal alter...
Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma
coexpression cell cycle arrest multiple myeloma hyperdiploid
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2016/1/20
Multiple myeloma is a hematological cancer of plasma B cells and remains incurable. Two major subtypes of myeloma, hyperdiploid MM (HMM) and non-hyperdiploid MM (NHMM), have distinct chromosomal alter...
Joint Modeling and Registration of Cell Populations in Cohorts of High-Dimensional Flow Cytometric Data
Joint Modeling Registration Cell Populations Cohorts High-Dimensional Flow Cytometric Data
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2013/6/14
In systems biomedicine, an experimenter encounters different potential sources of variation in data such as individual samples, multiple experimental conditions, and multi-variable network-level respo...
Object Oriented Data Analysis of Cell-Well Structured Data
data objects cell con uence bright
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2013/4/28
Object oriented data analysis (OODA) aims at statistically analyzing populations of complicated objects. This paper is motivated by a study of cell images in cell culture biology, which highlights a c...
Mixture Models for Single Cell Assays with Applications to Vaccine Studies
Mixture Models Single Cell Assays Applications to Vaccine Studies
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2012/9/18
Blood and tissue are composed of many functionally distinct cell subsets. In immunological studies, these can only be measured accurately using single-cell assays. The characterization of these small ...
Predictors of short-term decay of cell phone contacts in a large scale communication network
edge persistence edge decay link prediction dynamic networks embeddedness tie strength weighted networks
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2011/3/25
Under what conditions is an edge present in a social network at time t likely to decay or persist by some future time t + Delta(t)? Previous research addressing this issue suggests that the network ra...
Bayesian inference and model choice in a hidden stochastic two-compartment model of hematopoietic stem cell fate decisions
Stochastic two-compartment model hidden Markov models reversible jump MCMC hematopoiesis stem cell asymmetric division
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2010/11/8
Despite rapid advances in experimental cell biology, the in vivo behavior of hematopoietic stem cells (HSC) cannot be directly ob-served and measured. Previously we modeled feline hematopoiesis using ...
Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology
Microarrays, reproducibility forensic bioinformatics
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2010/10/19
High-throughput biological assays such as microarrays let us ask very detailed questions about how diseases operate, and promise to let us personalize therapy. Data processing, however, is often not d...
Statistical models to study subtoxic concentrations for some standard mutagens in three colon cancer cell lines
Inverse regression problem subtoxic concentration confidence interval
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2009/2/23
The aim of this work is to propose models to study the toxic effect of different concentrations of some standard mutagens in different colon cancer cell lines. We find estimates and, by means of an in...