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Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences...
Rewiring blood cells to give rise to precursors of sperm(图)     血细胞  精子前体  体细胞遗传学       font style='font-size:12px;'> 2023/7/5
Different cell types—say, heart, liver, blood, and sperm cells—possess characteristics that help them carry out their unique jobs in the body. In general, those characteristics are hard-wired. Without...
Uncovering how cells control their protein output(图)     蛋白质输出  细胞  Gene-Wei Li       font style='font-size:12px;'> 2023/6/5
A typical bacterial genome contains more than 4,000 genes, which encode all of the proteins that the cells need to survive. How do cells know just how much of each protein they need for their everyday...
Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.
Within a given tissue or organ, cells may appear very similar or even identical. But at the molecular level, these cells can have small differences that lead to wide variations in their functions.
Cells in complex organisms undergo frequent changes, and researchers have struggled to monitor these changes and create a comprehensive profile for living cells and tissues. Historically researchers h...
Study finds cells take out the trash before they divide(图)     细胞  分裂  清除垃圾       font style='font-size:12px;'> 2023/6/5
MIT researchers have discovered that before cells start to divide, they do a little cleanup, tossing out molecules that they appear not to need anymore.
Interaction with lung cells transforms asbestos particles(图)     肺细胞  相互作用  转化  石棉颗粒       font style='font-size:12px;'> 2023/7/11
Acommon building material, asbestos is the term used to describe a range of naturally growing minerals. Serious diseases, including mesothelioma and lung cancer, can arise decades after coming into co...
A new atlas of cells that carry blood to the brain(图)     血液  大脑  新细胞图谱  脑血管细胞       font style='font-size:12px;'> 2023/6/20
While neurons and glial cells are by far the most numerous cells in the brain, many other types of cells play important roles. Among those are cerebrovascular cells, which form the blood vessels that ...
Probing how proteins pair up inside cells(图)     蛋白质  配对  癌症  药物治疗       font style='font-size:12px;'> 2023/6/5
Despite its minute size, a single cell contains billions of molecules that bustle around and bind to one another, carrying out vital functions. The human genome encodes about 20,000 proteins, most of ...
New view of lymph nodes shows immune cells in real time(图)     淋巴结  新视图  免疫细胞       font style='font-size:12px;'> 2023/5/23
Cornell researchers have for the first time successfully imaged the entire depth of the lymph nodes in a living mouse using three-photon microscopy. The breakthrough technique’s micrometer clarity and...
In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disr...
Healthy sleep may rely on long-overlooked brain cells(图)     Healthy sleep  rely on  long-overlooked  jbrain cells       font style='font-size:12px;'> 2021/4/9
For something we spend one-third of our lives doing, we still understand remarkably little about how sleep works -- for example, why can some people sleep deeply through any disturbance, while others ...
Building on the promise of emerging therapies to deploy the body's "natural killer" immune cells to fight cancer, researchers at the University of Michigan have gone one step farther.They've...
Biochemists have helped answer a fundamental question that has lingered since the discovery of DNA: Is chromatin -- the complex package of DNA and proteins in the nucleus of our cells -- a solid or a ...

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