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朱卫国教授团队在《Nature Structural & Molecular Biology》发文揭示DNA损伤修复起始阶段染色质乙酰化的调控新机制（图）
DNA 朱卫国教授 生物学 赖氨酸
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2023/10/23
DNA损伤应答与修复经历“进入-修复-恢复” (Access-Repair-Restore，ARR）三个生物学过程。核小体稳态对于DNA损伤应答及信号解除、基因转录瞬时激活与抑制至关重要。单就组蛋白赖氨酸乙酰化来说，乙酰化介导染色质松弛以便DNA修复推进或促进基因转录；去乙酰化则造成致密染色质结构以保护遗传物质不受损失或抑制基因转录，因此染色质松散被认为是DNA双链断裂修复（DSBs）的先决条件。...
EVALUATING THE STRUCTURAL INTEGRITY OF THE SAINT ANTONIO BARREL VAULT IN THE FORTRESS OF ALMEIDA BY COMBINING LASER SCANNER AND LIMIT ANALYSIS
Historical construction Trace Italienne fortress Masonry Laser scanner Structural diagnosis Limit Analysis
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2019/3/4
Under the framework of the modern theory of restoration, this paper shows the experimental results obtained during the structural diagnosis of one of the most important master gates inside the militar...
SHAPE BASED CLASSIFICATION OF SEISMIC BUILDING STRUCTURAL TYPES
Seismic Building Structural Type Classification Machine Learning
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2018/11/9
This paper investigates automatic prediction of seismic building structural types described by the Global Earthquake Model (GEM) taxonomy, by combining remote sensing, cadastral and inspection data in...
SHAPE BASED CLASSIFICATION OF SEISMIC BUILDING STRUCTURAL TYPES
Seismic Building Structural Type Classification Machine Learning
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2018/11/9
This paper investigates automatic prediction of seismic building structural types described by the Global Earthquake Model (GEM) taxonomy, by combining remote sensing, cadastral and inspection data in...
GEOMATIC 3D MODELING OF A STATUE (ALSO) FOR STRUCTURAL ANALYSIS AND RISK EVALUATION: THE EXAMPLE OF SAN GIOVANNINO MARTELLI IN FLORENCE
Laser scanning 3D Modeling Cultural Heritage Structural Analysis Level of Detail Finite Element Method
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2017/6/20
This work has been developed among the researches of a PhD thesis in Civil and Environmental Engineering and Architecture of the University of Udine in cooperation with the GECO Laboratory of the Univ...
Genesis of structural features of humic acids from the sediments of a high productive coastal zone
humic acids Chakara (Mudbank) CP/MAS 13C NMR lignin moietiesar Basin
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2017/4/11
Chemical and physical properties of humic acids (HAs) isolated from Mudbanks (locally known as “Chakara”—a
unique phenomenon occurring along the south west coast of India during the southwest monsoon...
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
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2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
Ultrafast Excited-State Dynamics in the Green Fluorescent Protein Variant S65T/H148D.1.Mutagenesis and Structural Studies
Arabidopsis thaliana homogentisate phytyltransferase (HPT/VTE2) Lactuca sativa tocopherol tocopherol cyclase (TC/VTE1) vitamin e.
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2016/5/24
Wild type green fluorescent protein (wt-GFP) and the variant S65T/H148D each exhibit two absorption bands, A and B, which are associated with the protonated and deprotonated chromophores, respectively...
Green Fluorescent Protein Variants as Ratiometric Dual Emission pH Sensors.1.Structural Characterization and Preliminary Application
Animals Cricetulus Cell Line Threonine Luminescent Proteins Green Fluorescent Proteins Microscopy, Confocal Crystallography, X-Ray Transfection Amino Acid Substitution
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2016/5/24
Novel dual emission, pH-sensitive variants of the green fluorescent protein (GFP) have been constructed and are suitable for ratiometric emission measurements in vivo. This new class of GFPs, termed d...
19F NMR of Trifluoroacetyl-Labeled Cysteine Mutants of Myoglobin:Structural Probes of Nitric Oxide Bound to the H93G Cavity Mutant
19F NMR Trifluoroacetyl Cysteine Mutants Myoglobin Nitric Oxide H93G Cavity Mutant
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2016/5/23
Nitric oxide (NO) binds to the myoglobin (Mb) cavity mutant, H93G, forming either a 5- or 6-coordinate Fe--NO heme complex. The H93G mutation replaces the proximal histidine of Mb with glycine, allowi...
On the Origin of Heme Absorption Band Shifts and Associated Protein Structural Relaxation in Myoglobin Following Flash Photolysis
transhydrogenase NAD NADP Escherichia coli proton pump metal ion
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2016/5/23
The role of the protein structural change monitored by absorption band shifts following flash photolysis of CO from myoglobin is discussed in terms of structure-function relationships. Evidence is pre...
Excited State Energy Transfer Pathways in Photosynthetic Reaction Centers.1.Structural Symmetry Effects
biology and medicine,basic studies chemistry solar energy photosynthetic reaction centers energy transfer temperature dependence chemical reaction kinetics excited states molecular structure symmetry
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2016/5/23
Ultrafast excited state energy transfer to the primary electron donor or special pair in photosynthetic reaction centers has been measured following excitation of the lowest electronic state of the ot...
Multi-nuclear NMR Studies of DNA Hairpins:2.Sequence-Dependent Structural Variations
GERMANIUM DETERMINATION HYDRIDE GENERATION INDUCTIVELY COUPLED PLASMA EMISSION SPECTROMETRY MEDICINAL PLANT
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2016/5/20
The solution conformation of three related DNA hairpins, each with five bases in the loop, is investigated by proton and phosphorus 2D NMR methods. The sequences of the three oligomers are d(CGCGTTGTT...
A Structural Model for the Photosynthetic Reaction Center
Structural Model Photosynthetic Reaction Center
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2016/5/20
We describe here the synthesis and characterization of the solution conformation of a molecule which brings into close proximity the principal molecular components believed to participate in the initi...
Structural set-up of Southern Sinai and Gulf of Suez areas indicated by geophysical data
geomagnetic survey sub-surface structures aeromagnetic data seismic lines
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2015/9/17
This work deals with the evaluation of the structural set-up of the southern part of Sinai Peninsula, Gulf of Suez
and western part of Gulf of Suez from magnetic, gravity, and seismic data. The utili...