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Vibrational probes can provide a direct readout of the local electrostatic field in complex molecular environments, such as protein binding sites and enzyme active sites. This information provides an ...
Three different nitrile-containing amino acids, p-cyanophenylalanine, m-cyanophenylalanine, and S-cyanohomocysteine, have been introduced near the active site of the semisynthetic enzyme ribonuclease ...
The vibrational Stark effect (VSE) has proven to be an effective method for the study of electric fields in proteins via the use of infrared probes. To explore the use of VSE in nucleic acids, we inve...
Infrared spectroscopy is widely used to probe local environments and dynamics in proteins. The introduction of a unique vibration at a specific site of a protein or more complex assembly offers many a...
Nitric oxide (NO) binds to the myoglobin (Mb) cavity mutant, H93G, forming either a 5- or 6-coordinate Fe--NO heme complex. The H93G mutation replaces the proximal histidine of Mb with glycine, allowi...
Herbicides as Probes in Plant Biology     Molecular probe  herbicides as tools  chemical genetics  proteomics       font style='font-size:12px;'> 2015/12/21
Herbicides are small molecules that inhibit specific molecular target sites within plant biochemical pathways and/or physiological processes. Inhibition of these sites often has catastrophic consequen...
The mitotic chromosomes of Lablab purpureus (L.) Sweet were characterised using sequential combined propidium iodide (PI) and 4',6-diamidino-2-phenylindole (DAPI) (CPD) staining and fluorescence in si...
Mycoplasma gallisepticum (MG) and Mycoplasma synoviae (MS) are the most pathogenic and economically important mycoplasma pathogens that infect chickens. The development of rapid and innovative mol...
Cholesterol is an essential component of mammalian cell membranes and it is important to regulate the structure and function of lipid bilayers. Changes in cholesterol levels are involved in many physi...
Polyketides are a broad class of natural products that have received attention from the scientific community because they are a rich mine of bioactive structures. The common thread that binds the clas...
Probes, Goals and Syntactic Categories     Probes  Goals  Syntactic Categories       font style='font-size:12px;'> 2014/11/17
In this paper, we propose that when any two syntactic units are combined by the operation Merge, a "probe-goal" relation (Chomsky 2000; 2001) must be established between these elements. We call this t...
The box corer is a relatively new tool used in the geotechnical community for collection of soft seabed sediments. Miniature full flow and model pipeline probes were developed as tools to characterize...
The box corer is a relatively new tool used in the geotechnical community for collection of soft seabed sediments. Miniature full flow and model pipeline probes were developed as tools to characterize...
Galaxy clusters grow by mergers with other clusters and galaxy groups. These mergers create shocks within the intracluster medium (ICM). It is proposed that within the shocks particles can be accelera...

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